Catch You on the Flip Side: A Critical Review of Flippase Mutant Phenotypes
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Catch You on the Flip Side : A Critical Review of Flippase Mutant Phenotypes. / Nintemann, Sebastian J.; Palmgren, Michael; López-Marqués, Rosa Laura.
I: Trends in Plant Science, Bind 24, Nr. 5, 01.05.2019, s. 468-478.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Catch You on the Flip Side
T2 - A Critical Review of Flippase Mutant Phenotypes
AU - Nintemann, Sebastian J.
AU - Palmgren, Michael
AU - López-Marqués, Rosa Laura
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Lipid flippases are integral membrane proteins that use ATP hydrolysis to power the generation of phospholipid asymmetry between the two leaflets of biological membranes, a process essential for cell survival. Although the first report of a plant lipid flippase was published in 2000, progress in the field has been slow, partially due to the high level of redundancy in this gene family. However, recently an increasing number of reports have examined the physiological function of lipid flippases, mainly in Arabidopsis thaliana. In this review we aim to summarize recent findings on the physiological relevance of lipid flippases in plant adaptation to a changing environment and caution against misinterpretation of pleiotropic effects in genetic studies of flippases.
AB - Lipid flippases are integral membrane proteins that use ATP hydrolysis to power the generation of phospholipid asymmetry between the two leaflets of biological membranes, a process essential for cell survival. Although the first report of a plant lipid flippase was published in 2000, progress in the field has been slow, partially due to the high level of redundancy in this gene family. However, recently an increasing number of reports have examined the physiological function of lipid flippases, mainly in Arabidopsis thaliana. In this review we aim to summarize recent findings on the physiological relevance of lipid flippases in plant adaptation to a changing environment and caution against misinterpretation of pleiotropic effects in genetic studies of flippases.
KW - abiotic stress
KW - biotic stress
KW - lipid flippases
KW - membrane function
KW - P4 ATPases
KW - plant development
UR - http://www.scopus.com/inward/record.url?scp=85062956736&partnerID=8YFLogxK
U2 - 10.1016/j.tplants.2019.02.002
DO - 10.1016/j.tplants.2019.02.002
M3 - Review
C2 - 30885637
AN - SCOPUS:85062956736
VL - 24
SP - 468
EP - 478
JO - Trends in Plant Science
JF - Trends in Plant Science
SN - 1360-1385
IS - 5
ER -
ID: 224285612