Lipid somersaults - Employees

Department of Plant and Environmental Sciences

Lipid somersaults: uncovering the mechanisms of protein-mediated lipid flipping

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Lipid somersaults : uncovering the mechanisms of protein-mediated lipid flipping. / Günther-Pomorski, Thomas; Menon, Anant K.

In: Progress in Lipid Research, Vol. 64, 2016, p. 69-84.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Günther-Pomorski, T & Menon, AK 2016, 'Lipid somersaults: uncovering the mechanisms of protein-mediated lipid flipping', Progress in Lipid Research, vol. 64, pp. 69-84. https://doi.org/10.1016/j.plipres.2016.08.003

APA

Günther-Pomorski, T., & Menon, A. K. (2016). Lipid somersaults: uncovering the mechanisms of protein-mediated lipid flipping. Progress in Lipid Research, 64, 69-84. https://doi.org/10.1016/j.plipres.2016.08.003

Vancouver

Günther-Pomorski T, Menon AK. Lipid somersaults: uncovering the mechanisms of protein-mediated lipid flipping. Progress in Lipid Research. 2016;64:69-84. https://doi.org/10.1016/j.plipres.2016.08.003

Author

Günther-Pomorski, Thomas ; Menon, Anant K. / Lipid somersaults : uncovering the mechanisms of protein-mediated lipid flipping. In: Progress in Lipid Research. 2016 ; Vol. 64. pp. 69-84.

Bibtex

@article{1290384054164192937253899caf7d47,

title = "Lipid somersaults: uncovering the mechanisms of protein-mediated lipid flipping",

abstract = "Membrane lipids diffuse rapidly in the plane of the membrane but their ability to flip spontaneously across a membrane bilayer is hampered by a significant energy barrier. Thus spontaneous flip-flop of polar lipids across membranes is very slow, even though it must occur rapidly to support diverse aspects of cellular life. Here we discuss the mechanisms by which rapid flip-flop occurs, and what role lipid flipping plays in membrane homeostasis and cell growth. We focus on conceptual aspects, highlighting mechanistic insights from biochemical and in silico experiments, and the recent, ground-breaking identification of a number of lipid scramblases.",

author = "Thomas G{\"u}nther-Pomorski and Menon, {Anant K.}",

year = "2016",

doi = "10.1016/j.plipres.2016.08.003",

language = "English",

volume = "64",

pages = "69--84",

journal = "Progress in Lipid Research",

issn = "0163-7827",

publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Lipid somersaults

T2 - uncovering the mechanisms of protein-mediated lipid flipping

AU - Günther-Pomorski, Thomas

AU - Menon, Anant K.

PY - 2016

Y1 - 2016

N2 - Membrane lipids diffuse rapidly in the plane of the membrane but their ability to flip spontaneously across a membrane bilayer is hampered by a significant energy barrier. Thus spontaneous flip-flop of polar lipids across membranes is very slow, even though it must occur rapidly to support diverse aspects of cellular life. Here we discuss the mechanisms by which rapid flip-flop occurs, and what role lipid flipping plays in membrane homeostasis and cell growth. We focus on conceptual aspects, highlighting mechanistic insights from biochemical and in silico experiments, and the recent, ground-breaking identification of a number of lipid scramblases.

AB - Membrane lipids diffuse rapidly in the plane of the membrane but their ability to flip spontaneously across a membrane bilayer is hampered by a significant energy barrier. Thus spontaneous flip-flop of polar lipids across membranes is very slow, even though it must occur rapidly to support diverse aspects of cellular life. Here we discuss the mechanisms by which rapid flip-flop occurs, and what role lipid flipping plays in membrane homeostasis and cell growth. We focus on conceptual aspects, highlighting mechanistic insights from biochemical and in silico experiments, and the recent, ground-breaking identification of a number of lipid scramblases.

U2 - 10.1016/j.plipres.2016.08.003

DO - 10.1016/j.plipres.2016.08.003

M3 - Journal article

C2 - 27528189

VL - 64

SP - 69

EP - 84

JO - Progress in Lipid Research

JF - Progress in Lipid Research

SN - 0163-7827

ER -

ID: 168883700