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Dose-response analysis using R

Research output: Research - peer-reviewJournal article

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Christian Ritz, Florent Baty, Jens Carl Streibig, Daniel Gerhard

Dose-response analysis can be carried out using multi-purpose commercial statistical software, but except for a few special cases the analysis easily becomes cumbersome as relevant, non-standard output requires manual programming. The extension package drc for the statistical environment R provides a flexible and versatile infrastructure for dose-response analyses in general. The present version of the package, reflecting extensions and modifications over the last decade, provides a user-friendly interface to specify the model assumptions about the dose-response relationship and comes with a number of extractors for summarizing fitted models and carrying out inference on derived parameters. The aim of the present paper is to provide an overview of state-of-the-art dose-response analysis, both in terms of general concepts that have evolved and matured over the years and by means of concrete examples.

Original languageEnglish
Article numbere0146021
JournalP L o S One
Volume10
Issue number12
Number of pages13
ISSN1932-6203
DOIs
StatePublished - 2015

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