Pre-clinical evaluation of the effect of co-medication with antibiotics and oral steroids in Gottingen Minipigs on the biological activity of the probiotic medicinal product TSO (Trichuris suis ova)

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Pre-clinical evaluation of the effect of co-medication with antibiotics and oral steroids in Gottingen Minipigs on the biological activity of the probiotic medicinal product TSO (Trichuris suis ova). / Prosberg, M. V.; Kringel, H.; Kapel, J. S.; Kapel, B. S.; Fredensborg, B. L.; Petersen, A. M.; Hansen, L. H.; Nielsen, D. S.; Kapel, H. S.; Jacobsen, K. R.; Mikkelsen, L. F.; Kapel, C. M. O.

In: Parasitology Research, Vol. 120, 2021, p. 743-746.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Prosberg, MV, Kringel, H, Kapel, JS, Kapel, BS, Fredensborg, BL, Petersen, AM, Hansen, LH, Nielsen, DS, Kapel, HS, Jacobsen, KR, Mikkelsen, LF & Kapel, CMO 2021, 'Pre-clinical evaluation of the effect of co-medication with antibiotics and oral steroids in Gottingen Minipigs on the biological activity of the probiotic medicinal product TSO (Trichuris suis ova)', Parasitology Research, vol. 120, pp. 743-746. https://doi.org/10.1007/s00436-020-07004-8

APA

Prosberg, M. V., Kringel, H., Kapel, J. S., Kapel, B. S., Fredensborg, B. L., Petersen, A. M., Hansen, L. H., Nielsen, D. S., Kapel, H. S., Jacobsen, K. R., Mikkelsen, L. F., & Kapel, C. M. O. (2021). Pre-clinical evaluation of the effect of co-medication with antibiotics and oral steroids in Gottingen Minipigs on the biological activity of the probiotic medicinal product TSO (Trichuris suis ova). Parasitology Research, 120, 743-746. https://doi.org/10.1007/s00436-020-07004-8

Vancouver

Prosberg MV, Kringel H, Kapel JS, Kapel BS, Fredensborg BL, Petersen AM et al. Pre-clinical evaluation of the effect of co-medication with antibiotics and oral steroids in Gottingen Minipigs on the biological activity of the probiotic medicinal product TSO (Trichuris suis ova). Parasitology Research. 2021;120:743-746. https://doi.org/10.1007/s00436-020-07004-8

Author

Prosberg, M. V. ; Kringel, H. ; Kapel, J. S. ; Kapel, B. S. ; Fredensborg, B. L. ; Petersen, A. M. ; Hansen, L. H. ; Nielsen, D. S. ; Kapel, H. S. ; Jacobsen, K. R. ; Mikkelsen, L. F. ; Kapel, C. M. O. / Pre-clinical evaluation of the effect of co-medication with antibiotics and oral steroids in Gottingen Minipigs on the biological activity of the probiotic medicinal product TSO (Trichuris suis ova). In: Parasitology Research. 2021 ; Vol. 120. pp. 743-746.

Bibtex

@article{e2a8a4cbce344f619db003d642655170,
title = "Pre-clinical evaluation of the effect of co-medication with antibiotics and oral steroids in Gottingen Minipigs on the biological activity of the probiotic medicinal product TSO (Trichuris suis ova)",
abstract = "The probiotic medicinal product TSO (Trichuris suis ova) is administered to patients with active ulcerative colitis in an ongoing clinical phase IIb trial where the typical co-medications are steroids (prednisolone or budesonide) and antibiotics (e.g., phenoxymethylpenicillin). The present pre-clinical study evaluates the effects of these co-medications on the biological activity of TSO in Gottingen Minipigs. This translationally relevant pre-clinical model allows administration of TSO with and without oral steroids or antibiotics in a manner similar to the administration to patients, followed by quantification of the biological activity of TSO. The biological activity of TSO was not affected by oral steroids but was reduced by oral antibiotics. Fecal calprotectin, the common marker of intestinal inflammation in patients with UC, did not differ between groups.",
keywords = "Trichuris suis ova (TSO), Ulcerative colitis, Steroids, Antibiotics, COLITIS, MURIS",
author = "Prosberg, {M. V.} and H. Kringel and Kapel, {J. S.} and Kapel, {B. S.} and Fredensborg, {B. L.} and Petersen, {A. M.} and Hansen, {L. H.} and Nielsen, {D. S.} and Kapel, {H. S.} and Jacobsen, {K. R.} and Mikkelsen, {L. F.} and Kapel, {C. M. O.}",
year = "2021",
doi = "10.1007/s00436-020-07004-8",
language = "English",
volume = "120",
pages = "743--746",
journal = "Parasitology Research",
issn = "0932-0113",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Pre-clinical evaluation of the effect of co-medication with antibiotics and oral steroids in Gottingen Minipigs on the biological activity of the probiotic medicinal product TSO (Trichuris suis ova)

AU - Prosberg, M. V.

AU - Kringel, H.

AU - Kapel, J. S.

AU - Kapel, B. S.

AU - Fredensborg, B. L.

AU - Petersen, A. M.

AU - Hansen, L. H.

AU - Nielsen, D. S.

AU - Kapel, H. S.

AU - Jacobsen, K. R.

AU - Mikkelsen, L. F.

AU - Kapel, C. M. O.

PY - 2021

Y1 - 2021

N2 - The probiotic medicinal product TSO (Trichuris suis ova) is administered to patients with active ulcerative colitis in an ongoing clinical phase IIb trial where the typical co-medications are steroids (prednisolone or budesonide) and antibiotics (e.g., phenoxymethylpenicillin). The present pre-clinical study evaluates the effects of these co-medications on the biological activity of TSO in Gottingen Minipigs. This translationally relevant pre-clinical model allows administration of TSO with and without oral steroids or antibiotics in a manner similar to the administration to patients, followed by quantification of the biological activity of TSO. The biological activity of TSO was not affected by oral steroids but was reduced by oral antibiotics. Fecal calprotectin, the common marker of intestinal inflammation in patients with UC, did not differ between groups.

AB - The probiotic medicinal product TSO (Trichuris suis ova) is administered to patients with active ulcerative colitis in an ongoing clinical phase IIb trial where the typical co-medications are steroids (prednisolone or budesonide) and antibiotics (e.g., phenoxymethylpenicillin). The present pre-clinical study evaluates the effects of these co-medications on the biological activity of TSO in Gottingen Minipigs. This translationally relevant pre-clinical model allows administration of TSO with and without oral steroids or antibiotics in a manner similar to the administration to patients, followed by quantification of the biological activity of TSO. The biological activity of TSO was not affected by oral steroids but was reduced by oral antibiotics. Fecal calprotectin, the common marker of intestinal inflammation in patients with UC, did not differ between groups.

KW - Trichuris suis ova (TSO)

KW - Ulcerative colitis

KW - Steroids

KW - Antibiotics

KW - COLITIS

KW - MURIS

U2 - 10.1007/s00436-020-07004-8

DO - 10.1007/s00436-020-07004-8

M3 - Journal article

C2 - 33409625

VL - 120

SP - 743

EP - 746

JO - Parasitology Research

JF - Parasitology Research

SN - 0932-0113

ER -

ID: 256072579