Plant cytochromes P450: Tools for pharmacology, plant protection and phytoremediation
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Plant cytochromes P450 : Tools for pharmacology, plant protection and phytoremediation. / Morant, Marc; Bak, Søren; Møller, Birger Lindberg; Werck-Reichhart, Danièle.
In: Current Opinion in Biotechnology, Vol. 14, No. 2, 04.2003, p. 151-162.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Plant cytochromes P450
T2 - Tools for pharmacology, plant protection and phytoremediation
AU - Morant, Marc
AU - Bak, Søren
AU - Møller, Birger Lindberg
AU - Werck-Reichhart, Danièle
N1 - Funding Information: The support of Genoplante (DWR), Aventis Crops Science and the Association Nationale de la Recherche Technique (MM), the Danish National Research Foundation (SB, BLM) and the grant of a Marie Curie training fellowship (MM) are acknowledged.
PY - 2003/4
Y1 - 2003/4
N2 - Cytochromes P450 catalyse extremely diverse and often complex regiospecific and/or stereospecific reactions in the biosynthesis or catabolism of plant bioactive molecules. Engineered P450 expression is needed for low-cost production of antineoplastic drugs such as taxol or indole alkaloids and offers the possibility to increase the content of nutraceuticals such as phytoestrogens and antioxidants in plants. Natural products may serve important functions in plant defence and metabolic engineering of P450s is a prime target to improve plant defence against insects and pathogens. Herbicides, pollutants and other xenobiotics are metabolised by some plant P450 enzymes. These P450s are tools to modify herbicide tolerance, as selectable markers and for bioremediation.
AB - Cytochromes P450 catalyse extremely diverse and often complex regiospecific and/or stereospecific reactions in the biosynthesis or catabolism of plant bioactive molecules. Engineered P450 expression is needed for low-cost production of antineoplastic drugs such as taxol or indole alkaloids and offers the possibility to increase the content of nutraceuticals such as phytoestrogens and antioxidants in plants. Natural products may serve important functions in plant defence and metabolic engineering of P450s is a prime target to improve plant defence against insects and pathogens. Herbicides, pollutants and other xenobiotics are metabolised by some plant P450 enzymes. These P450s are tools to modify herbicide tolerance, as selectable markers and for bioremediation.
KW - Reverse transcription polymerase chain reaction
KW - RT-PCR
UR - http://www.scopus.com/inward/record.url?scp=0038404731&partnerID=8YFLogxK
U2 - 10.1016/S0958-1669(03)00024-7
DO - 10.1016/S0958-1669(03)00024-7
M3 - Review
C2 - 12732316
AN - SCOPUS:0038404731
VL - 14
SP - 151
EP - 162
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
SN - 0958-1669
IS - 2
ER -
ID: 347752148