Emerging properties and functional consequences of noncoding transcription

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Emerging properties and functional consequences of noncoding transcription. / Ard, Ryan; Allshire, Robin C; Marquardt, Sebastian.

In: Genetics (Print), Vol. 207, No. 2, 2017, p. 357-367.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ard, R, Allshire, RC & Marquardt, S 2017, 'Emerging properties and functional consequences of noncoding transcription', Genetics (Print), vol. 207, no. 2, pp. 357-367. https://doi.org/10.1534/genetics.117.300095

APA

Ard, R., Allshire, R. C., & Marquardt, S. (2017). Emerging properties and functional consequences of noncoding transcription. Genetics (Print), 207(2), 357-367. https://doi.org/10.1534/genetics.117.300095

Vancouver

Ard R, Allshire RC, Marquardt S. Emerging properties and functional consequences of noncoding transcription. Genetics (Print). 2017;207(2):357-367. https://doi.org/10.1534/genetics.117.300095

Author

Ard, Ryan ; Allshire, Robin C ; Marquardt, Sebastian. / Emerging properties and functional consequences of noncoding transcription. In: Genetics (Print). 2017 ; Vol. 207, No. 2. pp. 357-367.

Bibtex

@article{14e15369eff34d4bad8f0c8d2842952b,
title = "Emerging properties and functional consequences of noncoding transcription",
abstract = "Eukaryotic genomes are rich in transcription units encoding {"}long noncoding RNAs{"} (lncRNAs). The purpose of all this transcription is unclear since most lncRNAs are quickly targeted for destruction during synthesis or shortly thereafter. As debates continue over the functional significance of many specific lncRNAs, support grows for the notion that the act of transcription rather than the RNA product itself is functionally important in many cases. Indeed, this alternative mechanism might better explain how low-abundance lncRNAs transcribed from noncoding DNA function in organisms. Here, we highlight some of the recently emerging features that distinguish coding from noncoding transcription and discuss how these differences might have important implications for the functional consequences of noncoding transcription.",
keywords = "Journal Article",
author = "Ryan Ard and Allshire, {Robin C} and Sebastian Marquardt",
note = "Copyright {\textcopyright} 2017 by the Genetics Society of America.",
year = "2017",
doi = "10.1534/genetics.117.300095",
language = "English",
volume = "207",
pages = "357--367",
journal = "Genetics",
issn = "1943-2631",
publisher = "The Genetics Society of America (GSA)",
number = "2",

}

RIS

TY - JOUR

T1 - Emerging properties and functional consequences of noncoding transcription

AU - Ard, Ryan

AU - Allshire, Robin C

AU - Marquardt, Sebastian

N1 - Copyright © 2017 by the Genetics Society of America.

PY - 2017

Y1 - 2017

N2 - Eukaryotic genomes are rich in transcription units encoding "long noncoding RNAs" (lncRNAs). The purpose of all this transcription is unclear since most lncRNAs are quickly targeted for destruction during synthesis or shortly thereafter. As debates continue over the functional significance of many specific lncRNAs, support grows for the notion that the act of transcription rather than the RNA product itself is functionally important in many cases. Indeed, this alternative mechanism might better explain how low-abundance lncRNAs transcribed from noncoding DNA function in organisms. Here, we highlight some of the recently emerging features that distinguish coding from noncoding transcription and discuss how these differences might have important implications for the functional consequences of noncoding transcription.

AB - Eukaryotic genomes are rich in transcription units encoding "long noncoding RNAs" (lncRNAs). The purpose of all this transcription is unclear since most lncRNAs are quickly targeted for destruction during synthesis or shortly thereafter. As debates continue over the functional significance of many specific lncRNAs, support grows for the notion that the act of transcription rather than the RNA product itself is functionally important in many cases. Indeed, this alternative mechanism might better explain how low-abundance lncRNAs transcribed from noncoding DNA function in organisms. Here, we highlight some of the recently emerging features that distinguish coding from noncoding transcription and discuss how these differences might have important implications for the functional consequences of noncoding transcription.

KW - Journal Article

U2 - 10.1534/genetics.117.300095

DO - 10.1534/genetics.117.300095

M3 - Journal article

C2 - 28978770

VL - 207

SP - 357

EP - 367

JO - Genetics

JF - Genetics

SN - 1943-2631

IS - 2

ER -

ID: 184917035