Tomas Laursen

Tomas Laursen

Associate Professor


  1. 2023
  2. Published

    Exploiting photosynthesis-driven P450 activity to produce indican in tobacco chloroplasts

    Mellor, Silas Busck, Behrendorff, J. B. Y. H., Ipsen, J. O., Crocoll, C., Laursen, Tomas, Gillam, E. M. J. & Pribil, Mathias, 2023, In: Frontiers in Plant Science. 13, 17 p., 1049177.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 2022
  4. Published

    Biased metabolism via small-molecule ligands binding to P450 oxidoreductase

    Hatzakis, Nikos, Jensen, S. B., Thodberg, S., Parween, S., Moses, M. E., Hansen, C. C., Knudsen, C., Giudice, R. D., Lund, P. M., Castano, P., Bustamante, Y. G., Jorgennsen, F. S., Pandey, A. V., Laursen, Tomas & Møller, Birger Lindberg, 1 Feb 2022, In: Biophysical Journal. 121, 3, p. 52a 1 p., 250-Pos.

    Research output: Contribution to journalConference abstract in journalResearch

  5. Published

    Anthocyanic Vacuolar Inclusions: From Biosynthesis to Storage and Possible Applications

    Buhrman, K., Aravena Calvo, Javiera Patricia, Ross Zaulich, C., Hinz, Kasper & Laursen, Tomas, 2022, In: Frontiers in Chemistry. 10, 9 p., 913324.

    Research output: Contribution to journalReviewResearchpeer-review

  6. Published

    Expanding the Toolbox for Bicelle-Forming Surfactant–Lipid Mixtures

    Giudice, R. D., Paracini, N., Laursen, Tomas, Blanchet, C., Roosen-Runge, F. & Cárdenas, M., 2022, In: Molecules. 27, 21, 13 p., 7628.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Structure-guided engineering of key amino acids in UGT85B1 controlling substrate and stereo-specificity in aromatic cyanogenic glucoside biosynthesis

    Del Giudice, R., Putkaradze, N., dos Santos, B. M., Hansen, Cecilie Ida Cetti, Crocoll, C., Motawie, Mohammed Saddik, Fredslund, F., Laursen, Tomas & Welner, D. H., 2022, In: Plant Journal. 111, 6, p. 1539-1549

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2021
  9. Published

    Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase

    Jensen, S. B., Thodberg, S., Parween, S., Moses, M. E., Hansen, Cecilie Ida Cetti, Thomsen, J., Sletfjerding, M. B., Knudsen, C., Del Giudice, R., Lund, P. M., Castaño, P. R., Bustamante, Y. G., Velazquez, M. N. R., Jørgensen, Flemming Steen, Pandey, A. V., Laursen, Tomas, Møller, Birger Lindberg & Hatzakis, Nikos, 2021, In: Nature Communications. 12, 1, 14 p., 2260.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Membrane anchoring facilitates colocalization of enzymes in plant cytochrome P450 redox systems

    Laursen, Tomas, Lam, H. Y. M., Sorensen, K. K., Tian, P., Hansen, Cecilie Ida Cetti, Groves, J. T., Jensen, Knud Jørgen & Christensen, S. M., 2021, In: Communications Biology . 4, 9 p., 1057.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Metabolons and bio-condensates: The essence of plant plasticity and the key elements in development of green production systems

    Møller, Birger Lindberg & Laursen, Tomas, 2021, Advances in Botanical Research. Academic Press, p. 185-223 (Advances in Botanical Research, Vol. 97).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  12. 2020
  13. Published

    Stabilization of dhurrin biosynthetic enzymes from Sorghum bicolor using a natural deep eutectic solvent

    Knudsen, C., Bavishi, K., Viborg, K. M., Drew, D. P., Simonsen, H. T., Motawie, Mohammed Saddik, Møller, Birger Lindberg & Laursen, Tomas, 2020, In: Phytochemistry. 170, 9 p., 112214.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. 2019
  15. Published

    Molecular snapshots of dynamic membrane-bound metabolons

    Bassard, J. E. & Laursen, Tomas, 1 Jan 2019, Methods in Enzymology. Academic Press, Vol. 617. p. 1-27 27 p. (Methods in Enzymology, Vol. 617).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  16. 2018
  17. Published

    Natural Deep Eutectic Solvents for functionalization and storage of natural products and enzymes

    Baden, C. K., Montini, L., Bassard, J. A., Viborg, K. M., Jørgensen, Kirsten, Bjarnholt, Nanna, Møller, Birger Lindberg & Laursen, Tomas, 15 Jul 2018.

    Research output: Contribution to conferencePosterResearch

  18. Bifunctional glycosyltransferases catalyze both extension and termination of pectic galactan oligosaccharides

    Laursen, Tomas, Stonebloom, S. H., Pidatala, V. R., Birdseye, D. S., Clausen, M. H., Mortimer, J. C. & Scheller, H. V., 2018, In: Plant Journal. 94, 2, p. 340-351 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Direct observation of multiple conformational states in Cytochrome P450 oxidoreductase and their modulation by membrane environment and ionic strength

    Bavishi, K., Li, D., Eiersholt, S., Hooley, E. N., Petersen, Troels Christian, Møller, Birger Lindberg, Hatzakis, Nikos & Laursen, Tomas, 2018, In: Scientific Reports. 8, 9 p., 6817.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Dynamic metabolic solutions to the sessile life style of plants

    Baden, C. K., Gallage, N. J., Hansen, Cecilie Ida Cetti, Møller, Birger Lindberg & Laursen, Tomas, 2018, In: Natural Product Reports. 35, 11, p. 1140-1155 16 p.

    Research output: Contribution to journalReviewResearchpeer-review

  21. Published

    The Three Members of the Arabidopsis Glycosyltransferase Family 92 are Functional β-1,4-Galactan Synthases

    Ebert, B., Birdseye, D., Liwanag, A. J. M., Laursen, Tomas, Rennie, E. A., Guo, X., Catena, M., Rautengarten, C., Stonebloom, S. H., Gluza, P., Pidatala, V., Andersen, M. C. F., Cheetamun, R., Mortimer, J. C., Heazlewood, J. L., Bacic, A., Clausen, M. H., Willats, W. G. T. & Scheller, H. V., 2018, In: Plant and Cell Physiology. 59, 12, p. 2624-2636 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. 2017
  23. Published

    Assembly of dynamic P450-mediated metabolons - order versus chaos

    Bassard, J. A., Møller, Birger Lindberg & Laursen, Tomas, 2017, In: Current Biology. 3, 1, p. 37-51 15 p.

    Research output: Contribution to journalReviewResearchpeer-review

  24. Controlling styrene maleic acid lipid particles through RAFT

    Smith, A. A. A., Autzen, Henriette Elisabeth, Laursen, Tomas, Wu, V., Yen, M., Hall, A., Hansen, S. D., Cheng, Y. & Xu, T., 2017, In: Biomacromolecules. 18, 11, p. 3706-3713 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. 2016
  26. Published

    Application of nanodisc technology for direct electrochemical investigation of plant cytochrome P450s and their NADPH P450 oxidoreductase

    Bavishi, K., Laursen, Tomas, Martinez, Karen Laurence, Møller, Birger Lindberg & Della Pia, E. A., 2016, In: Scientific Reports. 6, 10 p., 29459.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum

    Laursen, Tomas, Borch-Jensen, J., Baden, C. K., Bavishi, K., Torta, F., Martens, Helle Jakobe, Silvestro, D., Hatzakis, Nikos, Wenk, M. R., Dafforn, T. R., Olsen, C. E., Motawie, Mohammed Saddik, Hamberger, B. R., Møller, Birger Lindberg & Bassard, J. A., 2016, In: Science (New York, N.Y.). 354, 6314, p. 890-893 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Evolution of NADPH-cytochrome P450 oxidoreductases (POR) in Apiales - POR 1 is missing

    Andersen, T. B., Hansen, N. B., Laursen, Tomas, Weitzel, C. & Simonsen, H. T., 2016, In: Molecular Phylogenetics and Evolution. 98, p. 21-28 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Links of conformational sampling to functional plasticity and clinical phenotypes by single molecule studies

    Moses, M. E., Thodberg, S., Bavishi, K., Eiersholt, S., Li, D., Stamou, Dimitrios, Møller, Birger Lindberg, Laursen, Tomas & Hatzakis, Nikos, 2016, In: Biophysical Society. Annual Meeting. Abstracts. 110, 3, p. 397A 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  30. 2015
  31. Published

    Nanodisc films for membrane protein studies by neutron reflection: effect of the protein scaffold choice

    Bertram, N., Laursen, Tomas, Barker, R., Bavishi, K., Møller, Birger Lindberg & Cardenas Gomez, M., 2015, In: Langmuir. 31, 30, p. 8386-8391 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Plasticity of specialized metabolism as mediated by dynamic metabolons

    Laursen, Tomas, Møller, Birger Lindberg & Bassard, J. A., 2015, In: Trends in Plant Science. 20, 1, p. 20-32 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. 2014
  34. Published

    Single molecule activity measurements of cytochrome P450 oxidoreductase reveal the existence of two discrete functional states

    Laursen, Tomas, Singha, A., Rantzau, N., Tutkus, M., Borch-Jensen, J., Hedegård, Per, Stamou, Dimitrios, Møller, Birger Lindberg & Hatzakis, Nikos, 2014, In: ACS chemical biology. 9, 3, p. 630-634 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. 2013
  36. Published

    Amphipol trapping of a functional CYP system

    Laursen, Tomas, Naur, P. & Møller, Birger Lindberg, 2013, In: Biotechnology and Applied Biochemistry. 60, 1, p. 119-127 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Isolation of monodisperse nanodisc-reconstituted membrane proteins using free flow electrophoresis

    Justesen, B. H., Laursen, Tomas, Weber, G., Fuglsang, Anja Thoe, Møller, Birger Lindberg & Pomorski, Thomas Guenther, 2013, In: Analytical Chemistry. 85, 7, p. 3497-3500 4 p.

    Research output: Contribution to journalLetterResearchpeer-review

  38. Published

    The binding of UDP-glucosyltransferase to the cytochrome P450s in dhurrin biosynthesis

    Baden, C. K., Laursen, Tomas, Kannangara, R. M., Bertram, N., Cardenas Gomez, M. & Møller, Birger Lindberg, 2013. 1 p.

    Research output: Contribution to conferencePosterResearch

  39. 2012
  40. Published

    A combined biochemical screen and TILLING approach identifies mutations in Sorghum bicolor L. Moench resulting in acyanogenic forage production

    Blomstedt, C. K., Gleadow, R. M., O'Donnell, N., Naur, P., Jensen, K., Laursen, Tomas, Olsen, C. E., Stuart, P., Hamill, J. D., Møller, Birger Lindberg & Neale, A. D., 2012, In: Plant Biotechnology Journal. 10, 1, p. 54-66 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Monitoring shifts in the conformation equilibrium of the membrane protein cytochrome P450 reductase (POR) in nanodiscs

    Wadsäter, M. H., Laursen, Tomas, Singha, A., Hatzakis, Nikos, Stamou, Dimitrios, Barker, R., Mortensen, Kell, Feidenhans'l, Robert Krarup, Møller, Birger Lindberg & Cardenas Gomez, M., 2012, In: Journal of Biological Chemistry. 287, 41, p. 34596-34603 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. 2011
  43. Published

    Conformational changes of the NADPH-dependent cytochrome P450 reductase in the course of electron transfer to cytochromes P450

    Laursen, Tomas, Jensen, K. & Møller, Birger Lindberg, 2011, In: Biochimica et Biophysica Acta - Proteins and Proteomics. 1814, 1, p. 132-138 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. 2009
  45. Published

    Functional expression of N-terminally tagged membrane bound cytochrome P450

    Hamann, T., Laursen, Tomas & Møller, Birger Lindberg, 2009, In: Protein Expression and Purification. 68, 1, p. 18-21 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 16022160