Kristian Erik Høpfner Frandsen

Kristian Erik Høpfner Frandsen

Assistant Professor


  1. 2013
  2. Published

    Binding of the N-terminal domain of the lactococcal bacteriophage TP901-1 CI repressor to its target DNA: a crystallography, small angle scattering, and nuclear magnetic resonance study

    Frandsen, Kristian Erik Høpfner, Rasmussen, K. K., Jensen, M. R., Hammer, K., Pedersen, M., Poulsen, Jens-Christian Navarro, Arleth, Lise & Lo Leggio, Leila, 2013, In: Biochemistry. 52, 39, p. 6892-6904 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 2015
  4. Published

    Structural diversity of lytic polysaccharide monooxygenases

    Lo Leggio, Leila, Frandsen, Kristian Erik Høpfner, Poulsen, Jens-Christian Navarro, Tovborg, M., De Maria, L. & Johansen, K. S., 2015, Proceedings of "Mie Bioforum 2014 - Lignocellulose Degradation and Biorefinery". Sakka, K., Kimura, T., Tamaru, Y., Karita, S. & Sakka, M. (eds.). UNI Publishers Co., Ltd, p. 148-156 9 p.

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

  5. Published

    Structure and boosting activity of a starch-degrading lytic polysaccharide monooxygenase

    Lo Leggio, Leila, Simmons, T. J., Poulsen, Jens-Christian Navarro, Frandsen, Kristian Erik Høpfner, Hemsworth, G. R., Stringer, M. A., von Freiesleben, P., Tovborg, M., Johansen, K. S., De Maria, L., Harris, P. V., Soong, C., Dupree, P., Tryfona, T., Lenfant, N., Henrissat, B., Davies, G. J. & Walton, P. H., 2015, In: Nature Communications. 6, 9 p., 5961.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 2016
  7. Published

    Lytic polysaccharide monooxygenases: a crystallographer's view on a new class of biomass-degrading enzymes

    Frandsen, Kristian Erik Høpfner & Lo Leggio, Leila, 2016, In: IUCrJ. 3, Part 6, p. 448-467 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Structural and dynamics studies of a truncated variant of CI repressor from bacteriophage TP901-1

    Rasmussen, K. K., Frandsen, Kristian Erik Høpfner, Boeri Erba, E., Pedersen, M., Varming, A. K., Hammer, K., Kilstrup, M., Thulstrup, Peter Waaben, Blackledge, M., Jensen, M. R. & Lo Leggio, Leila, 2016, In: Scientific Reports. 6, 12 p., 29574.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Structural characterization of Lytic Polysaccharide MonoOxygenases: Enzymatic interactions with lignocellulosic- and starch substrates

    Frandsen, Kristian Erik Høpfner, 2016, Department of Chemistry, Faculty of Science, University of Copenhagen.

    Research output: Book/ReportPh.D. thesisResearch

  10. Published

    The molecular basis of polysaccharide cleavage by lytic polysaccharide monooxygenases

    Frandsen, K. E. H., Simmons, T. J., Dupree, P., Poulsen, J-C. N., Hemsworth, G. R., Ciano, L., Johnston, E. M., Tovborg, M., Johansen, K. S., von Freiesleben, P., Marmuse, L., Fort, S., Cottaz, S., Driguez, H., Henrissat, B., Lenfant, N., Tuna, F., Baldansuren, A., Davies, G. J., Lo Leggio, L. & 1 others, Walton, P. H., 2016, In: Nature Chemical Biology. 12, 4, p. 298-303 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. 2017
  12. Published

    Learning from oligosaccharide soaks of crystals of an AA13 lytic polysaccharide monooxygenase: crystal packing, ligand binding and active-site disorder

    Frandsen, Kristian Erik Høpfner, Poulsen, Jens-Christian Navarro, Tovborg, M., Johansen, K. S. & Lo Leggio, Leila, 2017, In: Acta crystallographica Section D: Structural biology . 73, p. 64-76 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Structural and electronic determinants of lytic polysaccharide monooxygenase reactivity on polysaccharide substrates

    Simmons, T. J., Frandsen, Kristian Erik Høpfner, Ciano, L., Tryfona, T., Lenfant, N., Poulsen, Jens-Christian Navarro, Wilson, L. F. L., Tandrup, T., Tovborg, M., Schnorr, K., Johansen, K. S., Henrissat, B., Walton, P. H., Lo Leggio, Leila & Dupree, P., 2017, In: Nature Communications. 8, 12 p., 1064.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Unliganded and substrate bound structures of the cellooligosaccharide active lytic polysaccharide monooxygenase LsAA9A at low pH

    Frandsen, Kristian Erik Høpfner, Poulsen, Jens-Christian Navarro, Tandrup, T. & Lo Leggio, Leila, 2017, In: Carbohydrate Research. 448, p. 187-190 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. 2018
  16. Lytic xylan oxidases from wood-decay fungi unlock biomass degradation

    Couturier, M., Ladevèze, S., Sulzenbacher, G., Ciano, L., Fanuel, M., Moreau, C., Villares, A., Cathala, B., Chaspoul, F., Frandsen, K. E., Labourel, A., Herpoël-Gimbert, I., Grisel, S., Haon, M., Lenfant, N., Rogniaux, H., Ropartz, D., Davies, G. J., Rosso, M. N., Walton, P. H. & 2 others, Henrissat, B. & Berrin, J. G., 2018, In: Nature Chemical Biology. 14, 3, p. 306-310 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Recent insights into lytic polysaccharide monooxygenases (LPMOs)

    Tandrup, T., Frandsen, Kristian Erik Høpfner, Johansen, K. S., Berrin, J. & Lo Leggio, Leila, 2018, In: Biochemical Society Transactions. 46, 6, p. 1431-1447 17 p.

    Research output: Contribution to journalReviewResearchpeer-review

  18. Published

    Structural basis of the bacteriophage TP901‐1 CI repressor dimerization and interaction with DNA

    Rasmussen, K. K., Varming, A. K., Schmidt, S. N., Frandsen, Kristian Erik Høpfner, Thulstrup, Peter Waaben, Jensen, M. R. & Lo Leggio, Leila, 2018, In: F E B S Letters. 592, 10, p. 1738-1750 13 p.

    Research output: Contribution to journalLetterResearchpeer-review

  19. 2019
  20. Published

    Further structural studies of the lytic polysaccharide monooxygenase AoAA13 belonging to the starch-active AA13 family

    Muderspach, Sebastian Jannick, Tandrup, T., Frandsen, Kristian Erik Høpfner, Santoni, G., Poulsen, Jens-Christian Navarro & Lo Leggio, Leila, 2019, In: Amylase. 3, 1, p. 41-54 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Insights into an unusual Auxiliary Activity 9 family member lacking the histidine brace motif of lytic polysaccharide monooxygenases

    Frandsen, Kristian Erik Høpfner, Tovborg, M., Jørgensen, C. I., Spodsberg, N., Rosso, M., Hemsworth, G. R., Garman, E. F., Grime, G. W., Poulsen, Jens-Christian Navarro, Batth, T. S., Miyauchi, S., Lipzen, A., Daum, C., Grigoriev, I. V., Johansen, K. S., Henrissat, B., Berrin, J. & Lo Leggio, Leila, 2019, In: The Journal of Biological Chemistry. 294, p. 17117-17130 24 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. 2020
  23. Published

    A fungal family of lytic polysaccharide monooxygenase-like copper proteins

    Labourel, A., Frandsen, Kristian Erik Høpfner, Zhang, F., Brouilly, N., Grisel, S., Haon, M., Ciano, L., Ropartz, D., Fanuel, M., Martin, F., Navarro, D., Rosso, M., Tandrup, T., Bissaro, B., Johansen, K. S., Zerva, A., Walton, P. H., Henrissat, B., Lo Leggio, Leila & Berrin, J., 2020, In: Nature Chemical Biology. 16, p. 345-350 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Oligosaccharide Binding and Thermostability of Two Related AA9 Lytic Polysaccharide Monooxygenases

    Tandrup, T., Tryfona, T., Frandsen, Kristian Erik Høpfner, Johansen, K. S., Dupree, P. & Lo Leggio, Leila, 2020, In: Biochemistry. 59, 36, p. 3347-3358 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. 2021
  26. Published

    Inhibition of lytic polysaccharide monooxygenase by natural plant extracts

    Tokin, Radina, Frandsen, Kristian Erik Høpfner, Ipsen, J. Ø., Lo Leggio, Leila, Poojary, Mahesha Manjunatha, Berrin, J., Grisel, S., Brander, Søren, Jensen, Poul Erik & Johansen, K. S., 2021, In: New Phytologist. 232, 3, p. 1337–1349 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Identification of the molecular determinants driving the substrate specificity of fungal lytic polysaccharide monooxygenases (LPMOs)

    Frandsen, Kristian Erik Høpfner, Haon, M., Grisel, S., Henrissat, B., Lo Leggio, Leila & Berrin, J., 1 Jan 2021, In: Journal of Biological Chemistry. 296, 11 p., 100086.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. 2022
  29. Published

    Protonation State of an Important Histidine from High Resolution Structures of Lytic Polysaccharide Monooxygenases

    Banerjee, S., Muderspach, Sebastian Jannick, Tandrup, T., Frandsen, Kristian Erik Høpfner, Singh, R. K., Ipsen, J. O., Hernandez Rollan, Cristina, Nørholm, M. H. H., Bjerrum, Morten Jannik, Johansen, K. S. & Lo Leggio, Leila, 2022, In: Biomolecules. 12, 2, 15 p., 194.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. 2023
  31. Published

    Cellulose synthesis in land plants

    Pedersen, Gustav Blichfeldt, Blaschek, Leonard, Frandsen, Kristian Erik Høpfner, Noack, Lise Charlotte Marie & Persson, Staffan, 2023, In: Molecular Plant. 16, p. 206-231 26 p.

    Research output: Contribution to journalReviewResearchpeer-review

  32. Published

    The role of intrinsic disorder in binding of plant microtubule-associated proteins to the cytoskeleton

    Perez Gonzalez, Jordy, Frandsen, Kristian Erik Høpfner & Kesten, Christopher, 2023, In: Cytoskeleton. 80, 11-12, p. 404-436

    Research output: Contribution to journalReviewResearchpeer-review

  33. 2024
  34. Published

    NKS1/ELMO4 is an integral protein of a pectin synthesis protein complex and maintains Golgi morphology and cell adhesion in Arabidopsis

    Lathe, R. S., McFarlane, H. E., Kesten, Christopher, Wang, Liu, Khan, G. A., Ebert, B., Ramírez-Rodríguez, E. A., Zheng, Shuai, Noord, N., Frandsen, Kristian Erik Høpfner, Bhalerao, R. P. & Persson, Staffan, 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 15, 11 p., e2321759121.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Phosphate starvation regulates cellulose synthesis to modify root growth

    Khan, G. A., Dutta, A., Meene, A. V. D., Frandsen, Kristian Erik Høpfner, Ogden, Mike, Whelan, J. & Persson, Staffan, 2024, In: Plant Physiology. 194, 2, p. 1204-1217 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 40256638