Detection and characterization of Leishmania in tissues of patients with post kala-azar dermal leishmaniasis using a specific monoclonal antibody
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Detection and characterization of Leishmania in tissues of patients with post kala-azar dermal leishmaniasis using a specific monoclonal antibody. / Ismail, A; Kharazmi, A; Permin, H; el Hassan, A M.
In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 91, No. 3, 1997, p. 283-5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Detection and characterization of Leishmania in tissues of patients with post kala-azar dermal leishmaniasis using a specific monoclonal antibody
AU - Ismail, A
AU - Kharazmi, A
AU - Permin, H
AU - el Hassan, A M
N1 - Keywords: Animals; Antibodies, Monoclonal; Antibody Specificity; Antigens, Protozoan; Humans; Immunoenzyme Techniques; Leishmania donovani; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; Lymph Nodes; Skin
PY - 1997
Y1 - 1997
N2 - Sections from skin lesions and draining lymph nodes of patients with post kala-azar dermal leishmaniasis were examined using an immunoperoxidase method and a monoclonal antibody directed against Leishmania donovani. Parasites were detected in 22 of 25 biopsies (88%). In parallel sections stained by haematoxylin and eosin, parasites were detected in only 5 of 25 of the biopsies (20%). The demonstration of whole parasites or parasite antigen is diagnostic.
AB - Sections from skin lesions and draining lymph nodes of patients with post kala-azar dermal leishmaniasis were examined using an immunoperoxidase method and a monoclonal antibody directed against Leishmania donovani. Parasites were detected in 22 of 25 biopsies (88%). In parallel sections stained by haematoxylin and eosin, parasites were detected in only 5 of 25 of the biopsies (20%). The demonstration of whole parasites or parasite antigen is diagnostic.
M3 - Journal article
C2 - 9231195
VL - 91
SP - 283
EP - 285
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
SN - 0035-9203
IS - 3
ER -
ID: 18080500