ABA homeostasis and long-distance translocation are redundantly regulated by ABCG ABA importers
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- ABA homeostasis and long-distance translocation are redundantly regulated by ABCG ABA importers
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The effects of abscisic acid (ABA) on plant growth, development, and response to the environment depend on local ABA concentrations. Here, we show that in Arabidopsis, ABA homeostasis is regulated by two previously unknown ABA transporters. Adenosine triphosphate-binding cassette subfamily G member 17 (ABCG17) and ABCG18 are localized to the plasma membranes of leaf mesophyll and cortex cells to redundantly promote ABA import, leading to conjugated inactive ABA sinks, thus restricting stomatal closure. ABCG17 and ABCG18 double knockdown revealed that the transporters encoded by these genes not only limit stomatal aperture size, conductance, and transpiration while increasing water use efficiency but also control ABA translocation from the shoot to the root to regulate lateral root emergence. Under abiotic stress conditions, ABCG17 and ABCG18 are transcriptionally repressed, promoting active ABA movement and response. The transport mechanism mediated by ABCG17 and ABCG18 allows plants to maintain ABA homeostasis under normal growth conditions.
Originalsprog | Engelsk |
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Artikelnummer | eabf6069 |
Tidsskrift | Science Advances |
Vol/bind | 7 |
Udgave nummer | 43 |
Antal sider | 18 |
ISSN | 2375-2548 |
DOI | |
Status | Udgivet - 2021 |
Bibliografisk note
Funding Information:
This work was supported by grants from the Israel Science Foundation (2378/19 and 3419/20 to E.S.), the Human Frontier Science Program (HFSP-RGY0075/2015 and HFSP-LIY000540/2020 to E.S. and H.H.N.-E.), Danmarks Grundforskningsfond (DNRF99 to H.H.N.-E.), the European Research Council (757683-RobustHormoneTrans to E.S. and 679189 GAtransport to R.W.), the PBC postdoctoral fellowship (to Y.Z.), and the ADAMA Center for Novel Delivery Systems in Crop Protection fellowship (to S.L.) and by the Swiss National Funds (31003A-165877/1 to M.G.). Author
Publisher Copyright:
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science.
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