PTR2/POT/NPF transporters: what makes them tick?
Research output: Contribution to journal › Review › Research › peer-review
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PTR2/POT/NPF transporters : what makes them tick? / Prabhala, Bala K.; Rahman, Moazur; Nour-Eldin, Hussam H; Jørgensen, Flemming Steen; Mirza, Osman.
In: Advances in Protein Chemistry and Structural Biology, Vol. 123, 2021, p. 219-240.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - PTR2/POT/NPF transporters
T2 - what makes them tick?
AU - Prabhala, Bala K.
AU - Rahman, Moazur
AU - Nour-Eldin, Hussam H
AU - Jørgensen, Flemming Steen
AU - Mirza, Osman
N1 - Copyright © 2021 Elsevier Inc. All rights reserved.
PY - 2021
Y1 - 2021
N2 - PTR2/POT/NPF are a family of primarily proton coupled transporters that belong to the major facilitator super family and are found across most kingdoms of life. They are involved in uptake of nutrients, hormones, ions and several orally administered drug molecules. A wealth of structural and functional data is available for this family; the similarity between the protein structural features have been discussed and investigated in detail on several occasions, however there are no reports on the unification of substrate information. In order to fill this gap, we have collected information about substrates across the entire PTR2/POT/NPF family in order to provide key insights into what makes a molecule a substrate and whether there are common features among confirmed substrates. This review will be of particular interest for researchers in the field trying to probe the mechanisms responsible for the different selectivity of these transporters at a molecular resolution, and to design novel substrates.
AB - PTR2/POT/NPF are a family of primarily proton coupled transporters that belong to the major facilitator super family and are found across most kingdoms of life. They are involved in uptake of nutrients, hormones, ions and several orally administered drug molecules. A wealth of structural and functional data is available for this family; the similarity between the protein structural features have been discussed and investigated in detail on several occasions, however there are no reports on the unification of substrate information. In order to fill this gap, we have collected information about substrates across the entire PTR2/POT/NPF family in order to provide key insights into what makes a molecule a substrate and whether there are common features among confirmed substrates. This review will be of particular interest for researchers in the field trying to probe the mechanisms responsible for the different selectivity of these transporters at a molecular resolution, and to design novel substrates.
KW - Animals
KW - Biological Transport
KW - Humans
KW - Membrane Transport Proteins/chemistry
KW - Substrate Specificity
U2 - 10.1016/bs.apcsb.2020.10.002
DO - 10.1016/bs.apcsb.2020.10.002
M3 - Review
C2 - 33485485
VL - 123
SP - 219
EP - 240
JO - Advances in Protein Chemistry and Structural Biology
JF - Advances in Protein Chemistry and Structural Biology
SN - 1876-1623
ER -
ID: 272115649