Gut microbiota research nexus: One Health relationship between human, animal, and environmental resistomes
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Gut microbiota research nexus : One Health relationship between human, animal, and environmental resistomes. / Fu, Yuhao; Dou, Qingyuan; Smalla, Kornelia; Wang, Yu; Johnson, Timothy A.; Brandt, Kristian K.; Mei, Zhi; Liao, Maoyuan; Hashsham, Syed A.; Schäffer, Andreas; Smidt, Hauke; Zhang, Tong; Li, Hui; Stedtfeld, Robert; Sheng, Hongjie; Chai, Benli; Virta, Marko; Jiang, Xin; Wang, Fang; Zhu, Yong Guan; Tiedje, James M.
In: mLife, Vol. 2, No. 4, 2023, p. 350-364.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Gut microbiota research nexus
T2 - One Health relationship between human, animal, and environmental resistomes
AU - Fu, Yuhao
AU - Dou, Qingyuan
AU - Smalla, Kornelia
AU - Wang, Yu
AU - Johnson, Timothy A.
AU - Brandt, Kristian K.
AU - Mei, Zhi
AU - Liao, Maoyuan
AU - Hashsham, Syed A.
AU - Schäffer, Andreas
AU - Smidt, Hauke
AU - Zhang, Tong
AU - Li, Hui
AU - Stedtfeld, Robert
AU - Sheng, Hongjie
AU - Chai, Benli
AU - Virta, Marko
AU - Jiang, Xin
AU - Wang, Fang
AU - Zhu, Yong Guan
AU - Tiedje, James M.
N1 - Publisher Copyright: © 2023 The Authors. mLife published by John Wiley & Sons Australia, Ltd on behalf of Institute of Microbiology, Chinese Academy of Sciences.
PY - 2023
Y1 - 2023
N2 - The emergence and rapid spread of antimicrobial resistance is of global public health concern. The gut microbiota harboring diverse commensal and opportunistic bacteria that can acquire resistance via horizontal and vertical gene transfers is considered an important reservoir and sink of antibiotic resistance genes (ARGs). In this review, we describe the reservoirs of gut ARGs and their dynamics in both animals and humans, use the One Health perspective to track the transmission of ARG-containing bacteria between humans, animals, and the environment, and assess the impact of antimicrobial resistance on human health and socioeconomic development. The gut resistome can evolve in an environment subject to various selective pressures, including antibiotic administration and environmental and lifestyle factors (e.g., diet, age, gender, and living conditions), and interventions through probiotics. Strategies to reduce the abundance of clinically relevant antibiotic-resistant bacteria and their resistance determinants in various environmental niches are needed to ensure the mitigation of acquired antibiotic resistance. With the help of effective measures taken at the national, local, personal, and intestinal management, it will also result in preventing or minimizing the spread of infectious diseases. This review aims to improve our understanding of the correlations between intestinal microbiota and antimicrobial resistance and provide a basis for the development of management strategies to mitigate the antimicrobial resistance crisis.
AB - The emergence and rapid spread of antimicrobial resistance is of global public health concern. The gut microbiota harboring diverse commensal and opportunistic bacteria that can acquire resistance via horizontal and vertical gene transfers is considered an important reservoir and sink of antibiotic resistance genes (ARGs). In this review, we describe the reservoirs of gut ARGs and their dynamics in both animals and humans, use the One Health perspective to track the transmission of ARG-containing bacteria between humans, animals, and the environment, and assess the impact of antimicrobial resistance on human health and socioeconomic development. The gut resistome can evolve in an environment subject to various selective pressures, including antibiotic administration and environmental and lifestyle factors (e.g., diet, age, gender, and living conditions), and interventions through probiotics. Strategies to reduce the abundance of clinically relevant antibiotic-resistant bacteria and their resistance determinants in various environmental niches are needed to ensure the mitigation of acquired antibiotic resistance. With the help of effective measures taken at the national, local, personal, and intestinal management, it will also result in preventing or minimizing the spread of infectious diseases. This review aims to improve our understanding of the correlations between intestinal microbiota and antimicrobial resistance and provide a basis for the development of management strategies to mitigate the antimicrobial resistance crisis.
KW - antibiotic
KW - antimicrobial resistance
KW - gut microbiota
KW - modulatory strategies
KW - One Health
U2 - 10.1002/mlf2.12101
DO - 10.1002/mlf2.12101
M3 - Review
AN - SCOPUS:85180665588
VL - 2
SP - 350
EP - 364
JO - mLife
JF - mLife
SN - 2097-1699
IS - 4
ER -
ID: 379716331