Elevated virulence of an emerging viral genotype as a driver of honeybee loss
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Elevated virulence of an emerging viral genotype as a driver of honeybee loss. / McMahon, Dino P.; Natsopoulou, Myrsini Eirini; Doublet, Vincent; Fürst, Matthias; Weging, Silvio; Brown, Mark J F; Gogol-Döring, Andreas; Paxton, Robert J.
In: Proceedings of the Royal Society B: Biological Sciences, Vol. 283, No. 1833, 20160811, 2016.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Elevated virulence of an emerging viral genotype as a driver of honeybee loss
AU - McMahon, Dino P.
AU - Natsopoulou, Myrsini Eirini
AU - Doublet, Vincent
AU - Fürst, Matthias
AU - Weging, Silvio
AU - Brown, Mark J F
AU - Gogol-Döring, Andreas
AU - Paxton, Robert J.
PY - 2016
Y1 - 2016
N2 - Emerging infectious diseases (EIDs) have contributed significantly to the current biodiversity crisis, leading to widespread epidemics and population loss. Owing to genetic variation in pathogen virulence, a complete understanding of species decline requires the accurate identification and characterization of EIDs. We explore this issue in the Western honeybee, where increasing mortality of populations in the Northern Hemisphere has caused major concern. Specifically, we investigate the importance of genetic identity of the main suspect in mortality, deformed wing virus (DWV), in driving honeybee loss. Using laboratory experiments and a systematic field survey, we demonstrate that an emerging DWV genotype (DWV-B) is more virulent than the established DWV genotype (DWV-A) and is widespread in the landscape. Furthermore, we show in a simple model that colonies infected with DWV-B collapse sooner than colonies infected with DWV-A. We also identify potential for rapid DWV evolution by revealing extensive genome-wide recombination in vivo. The emergence of DWV-B in naive honeybee populations, including via recombination with DWV-A, could be of significant ecological and economic importance. Our findings emphasize that knowledge of pathogen genetic identity and diversity is critical to understanding drivers of species decline.
AB - Emerging infectious diseases (EIDs) have contributed significantly to the current biodiversity crisis, leading to widespread epidemics and population loss. Owing to genetic variation in pathogen virulence, a complete understanding of species decline requires the accurate identification and characterization of EIDs. We explore this issue in the Western honeybee, where increasing mortality of populations in the Northern Hemisphere has caused major concern. Specifically, we investigate the importance of genetic identity of the main suspect in mortality, deformed wing virus (DWV), in driving honeybee loss. Using laboratory experiments and a systematic field survey, we demonstrate that an emerging DWV genotype (DWV-B) is more virulent than the established DWV genotype (DWV-A) and is widespread in the landscape. Furthermore, we show in a simple model that colonies infected with DWV-B collapse sooner than colonies infected with DWV-A. We also identify potential for rapid DWV evolution by revealing extensive genome-wide recombination in vivo. The emergence of DWV-B in naive honeybee populations, including via recombination with DWV-A, could be of significant ecological and economic importance. Our findings emphasize that knowledge of pathogen genetic identity and diversity is critical to understanding drivers of species decline.
KW - Decline
KW - Emerging infectious disease
KW - Pollinator
KW - Virulence
U2 - 10.1098/rspb.2016.0811
DO - 10.1098/rspb.2016.0811
M3 - Journal article
C2 - 27358367
AN - SCOPUS:84976266043
VL - 283
JO - Proceedings of the Royal Society B: Biological Sciences
JF - Proceedings of the Royal Society B: Biological Sciences
SN - 0962-8452
IS - 1833
M1 - 20160811
ER -
ID: 167550864