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Aktuel forskning

Basic research question: How do plants communicate? Plants produce chemical languages to communicate. From the site of synthesis to their site of function, those chemicals need to cross internal borders (e.g. at the maternal-filial interface) and cross external borders (e.g. interface between plant epidermis and phyllosphere and rhizosphere).

Impact: Elucidating molecular mechanisms underlying plant communication will provide breeding targets to improve seed nutritional value (e.g. removing antinutritional compounds) and plant resilience to (a)biotic stress. Currently, I implement single-cell sequencing and spatial transcriptomics to identify key genes expressed at the essential cellular transport barriers in major oilseed crops. Ultimately, I want to develop oilseed crops as ideal protein sources for human consumption in sustainable agriculture.

Expertise: Plant membrane transport of specialized metabolites/Pathway and transport engineering/Gene discovery using multi-omics

I have been using glucosinolate defense compounds as a model system to study the molecular and cellular mechanisms underlying the synthesis, transport and storage of metabolites and their biological significance in plant communication, including but not limited to the following three subareas:

• Identification and characterization of transporter complement of glucosinolate defence compounds
• Pathway and transport engineering of specialized metabolites to improve crop quality
• Chemical communication in beneficial plant-microbe interaction

 

First and/or corresponding authors of 9 peer-reviewed papers in high-ranking journals (E.g. Nature, Nature Plants, Molecular Plant). Grantee of >10M DKK in external funding. Speaker at high-profile international forums and conferences (e.g. Plant Biology Europe, International Workshop on Plant Membrane Biology). Danish representative of the international PlantACT initiative. Active referee of journals (E.g. Molecular Plant, Plant Communication, Plant Physiology, Plant Biotechnology Journal, New Phytologist) and editorial board member of journals (e.g. Science China Life Sciences and Fundamental Research). Active in teaching, censor and supervision (supervised 20+ PhD, MSc and BSc students and 2 postdocs).

External funding

2024-2025	PI in Innoexplorer Innovation Foundation Denmark (DKK 1.5M)
2023-2026	PI in Project Grant,Novo Nordisk Foundation, (DKK 3.0M)
2023-2024 2023-2024   2023-2024 2023-2027	PI in Innoexplorer, Innovation Foundation Denmark (DKK 1.5M) co-applicant in Pioneer Innovator, Novo Nordisk Foundation, (DKK 1M) Co-PI GSC living lab (297.000 DKK) PI in Research Project 1, DFF-FNU (DKK 2.9 M)
2021-2027	Co-PI in Villum Investigator Program, Partner (DKK 30M)

Undervisnings- og vejledningsområder

Certificate Teaching and Learning in Higher Education (Universitetspædagogikum) (2019)

PhDs: Line Lykke Hansen (Denmark), Laura Dethier (Belgium), Shiwen Yang (China), Fangfei Niu (China)

             From April 2024, three new PhDs on rapeseed (2) and plant microbiome (1)

Postdocs: Niels Christian Holm Sanden (Denmark), Carmina Falcato Cabral (Portugal)

BSc and MSc students: 9 MSc theses, 1 BSc thesis, 3 ERASMUS internship MSc students and 4 DAAD internship BSc students, 3 Projects outside course scope (PUK)

Lectures: Frontiers in Plant Science MSc (2024), Experimental Molecular Biology (EMB), BSc course (2020-2023)

                Bioactive Food Components and Health (2019)

   Lab exercises: Lab exercise in EMB, BSc course (2020-2023), Biochemistry, BSc course, (2021-2022)

Student feedback on supervision:  https://www.linkedin.com/in/deyang-xu-778b1358/details/recommendations/

Udvalgte publikationer

1. Udgivet

   An UMAMIT-GTR transporter cascade controls glucosinolate seed loading in Arabidopsis

   Sanden, Niels Christian Holm, Kanstrup, Christa, Crocoll, C., Schulz, Alexander, Nour-Eldin, Hussam Hassan, Halkier, Barbara Ann & Xu, Deyang, 2024, I: Nature Plants. 10, s. 172-179

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

2. Udgivet

   Export of defensive glucosinolates is key for their accumulation in seeds

   Xu, Deyang, Sanden, Niels Christian Holm, Hansen, Line Lykke, Belew, Zeinu Mussa, Madsen, S. R., Meyer, L., Jørgensen, M. E., Hunziker, P., Veres, D., Crocoll, C., Schulz, Alexander, Nour-Eldin, Hussam Hassan & Halkier, Barbara Ann, 2023, I: Nature. 617, s. 132-138

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

3. Udgivet

   GTR-Mediated Radial Import Directs Accumulation of Defensive Glucosinolates to Sulfur-Rich Cells in the Phloem Cap of Arabidopsis Inflorescence Stem

   Xu, Deyang, Hunziker, P., Koroleva, O., Blennow, Andreas, Crocoll, C., Schulz, Alexander, Nour-Eldin, Hussam Hassan & Halkier, Barbara Ann, 2019, I: Molecular Plant. 12, 11, s. 1474-1484

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

4. Udgivet

   The ins and outs of transporters at plasma membrane and tonoplast in plant specialized metabolism: [Correction]

   Xu, Deyang & Halkier, Barbara Ann, 2022, I: Natural Product Reports. 39, 7, s. 1483-1491

   Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

5. Udgivet

   Harnessing beneficial microbes from Danish natural soils to biostimulate plant nutrition

   Xu, Deyang, Dethier, L. & Halkier, Barbara Ann, 13 nov. 2022.

   Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning

6. Udgivet

   An NPF transporter exports a central monoterpene indole alkaloid intermediate from the vacuole

   Payne, R., Xu, Deyang, Foureau, E., Ines Soares Teto Carqueijeiro, M., Oudin, A., Dugé de Bernonville, T., Novák, V., Burow, Meike, Olsen, C. E., Jones, D. M., C. Tatsis, E., Pendleton, A., Halkier, Barbara Ann, Geu-Flores, Fernando, Courdavault, V., Nour-Eldin, Hussam Hassan & O'Connor, S. E., 2017, I: Nature Plants. 3, 9 s., 16208.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

7. Udgivet

   Origin and evolution of transporter substrate specificity within the NPF family: [with Correction]

   Jørgensen, M. E., Xu, Deyang, Crocoll, C., Ernst, H. A., Ramírez, D., Motawie, Mohammed Saddik, Olsen, C. E., Mirza, Osman Asghar, Nour-Eldin, Hussam Hassan & Halkier, Barbara Ann, 2017, I: eLife. 6, 30 s., e19466.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

8. Udgivet

   Rhizosecretion of stele-synthesized glucosinolates and their catabolites requires GTR-mediated import in Arabidopsis

   Xu, Deyang, Hanschen, F. S., Witzel, K., Kjeldgaard-Nintemann, Sebastian J, Nour-Eldin, Hussam Hassan, Schreiner, M. & Halkier, Barbara Ann, 2017, I: Journal of Experimental Botany. 68, 12, s. 3205-3214 10 s.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt