Histone demethylases and cancer

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Standard

Histone demethylases and cancer. / Kampranis, Sotirios; Tsichlis, Philip N.

I: Advances in Cancer Research, Bind 102, 2009, s. 103-69.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Kampranis, S & Tsichlis, PN 2009, 'Histone demethylases and cancer', Advances in Cancer Research, bind 102, s. 103-69. https://doi.org/10.1016/S0065-230X(09)02004-1

APA

Kampranis, S., & Tsichlis, P. N. (2009). Histone demethylases and cancer. Advances in Cancer Research, 102, 103-69. https://doi.org/10.1016/S0065-230X(09)02004-1

Vancouver

Kampranis S, Tsichlis PN. Histone demethylases and cancer. Advances in Cancer Research. 2009;102:103-69. https://doi.org/10.1016/S0065-230X(09)02004-1

Author

Kampranis, Sotirios ; Tsichlis, Philip N. / Histone demethylases and cancer. I: Advances in Cancer Research. 2009 ; Bind 102. s. 103-69.

Bibtex

@article{955f0ceb34454f6a8eb066a1e5f78dda,
title = "Histone demethylases and cancer",
abstract = "Epigenetic modifications are heritable chromatin alterations that contribute to the temporal and spatial interpretation of the genome. The epigenetic information is conveyed through a multitude of chemical modifications, including DNA methylation, reversible modifications of histones, and ATP-dependent nucleosomal remodeling. Deregulation of the epigenetic machinery contributes to the development of several pathologies, including cancer. Chromatin modifications are multiple and interdependent and they are dynamically modulated in the course of various biological processes. Combinations of chromatin modifications give rise to a complex code that is superimposed on the genetic code embedded into the DNA sequence to regulate cell function. This review addresses the role of epigenetic modifications in cancer, focusing primarily on histone methylation marks and the enzymes catalyzing their removal.",
keywords = "Animals, DNA Methylation, Epigenesis, Genetic, Histones, Humans, Neoplasms, Oxidoreductases, N-Demethylating",
author = "Sotirios Kampranis and Tsichlis, {Philip N}",
year = "2009",
doi = "10.1016/S0065-230X(09)02004-1",
language = "English",
volume = "102",
pages = "103--69",
journal = "Advances in Cancer Research",
issn = "0065-230X",
publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Histone demethylases and cancer

AU - Kampranis, Sotirios

AU - Tsichlis, Philip N

PY - 2009

Y1 - 2009

N2 - Epigenetic modifications are heritable chromatin alterations that contribute to the temporal and spatial interpretation of the genome. The epigenetic information is conveyed through a multitude of chemical modifications, including DNA methylation, reversible modifications of histones, and ATP-dependent nucleosomal remodeling. Deregulation of the epigenetic machinery contributes to the development of several pathologies, including cancer. Chromatin modifications are multiple and interdependent and they are dynamically modulated in the course of various biological processes. Combinations of chromatin modifications give rise to a complex code that is superimposed on the genetic code embedded into the DNA sequence to regulate cell function. This review addresses the role of epigenetic modifications in cancer, focusing primarily on histone methylation marks and the enzymes catalyzing their removal.

AB - Epigenetic modifications are heritable chromatin alterations that contribute to the temporal and spatial interpretation of the genome. The epigenetic information is conveyed through a multitude of chemical modifications, including DNA methylation, reversible modifications of histones, and ATP-dependent nucleosomal remodeling. Deregulation of the epigenetic machinery contributes to the development of several pathologies, including cancer. Chromatin modifications are multiple and interdependent and they are dynamically modulated in the course of various biological processes. Combinations of chromatin modifications give rise to a complex code that is superimposed on the genetic code embedded into the DNA sequence to regulate cell function. This review addresses the role of epigenetic modifications in cancer, focusing primarily on histone methylation marks and the enzymes catalyzing their removal.

KW - Animals

KW - DNA Methylation

KW - Epigenesis, Genetic

KW - Histones

KW - Humans

KW - Neoplasms

KW - Oxidoreductases, N-Demethylating

U2 - 10.1016/S0065-230X(09)02004-1

DO - 10.1016/S0065-230X(09)02004-1

M3 - Journal article

C2 - 19595308

VL - 102

SP - 103

EP - 169

JO - Advances in Cancer Research

JF - Advances in Cancer Research

SN - 0065-230X

ER -

ID: 159084995