Signalperception ved celleoverfladen og transduktion af dette signal til cellens indre er afgørende for alle livsformer. Planter har udviklet membranintegrale receptorproteiner og nedstrøms signaleringskaskader, der tillader dem at reagere på eksterne stimuli og koordinere deres vækst.

Vi er interesserede i plantens reaktioner på både biotiske og abiotiske stimuli. Ét område dækker rollen af ​​plasmamembranens H+-ATPaser og signalerne involveret i regulering af dette, til vækst og udvikling essentielle enzym, samt dets reaktioner på eksterne stimuli. Et andet interesseområde er plante- og svampereceptorer til genkendelse af bakterielle ydre cellevægsmolekyler, de efterfølgende signalveje i eukaryote værter samt de kemiske strukturer og syntesen af nogle af disse bakterielle molekyler.

Forskningstemaer

  • PSY1 signalling peptides and their receptor PSY1R. The project is a basic research project aiming at under standing the perception of a peptide hormone that has the plasma membrane H+-ATPase as a downstream target.

  • Screening for compounds with regulatory effects on plant and fungal plasma membrane H+-ATPase

  • Regulation of the plant plasma membrane H+-ATPase by kinases and phosphatases in response to abiotic and biotic stimuli

  • Perception and signaling by bacteria and bacterial microbe-associated molecular patterns (MAMPs) in plants

  • Structures and functions of glycosylated MAMPs

Forskningsprojekter

  • COMBAT “Combating microbial invasion through the stomatal pore”

  • Understanding the mechanisms in plants that lead to restriction of pathogen growth will both yield valuable biological information and help us improve plants used for food, feed and fuel in the future. We hypothesize that pathogens have developed a general mechanism by which they interfere with the signal transduction pathways controlling closure and opening of the plant stomatal apparatus. We will identify and describe the molecular mechanisms of such components in a screen based on fungal extracts. Combined with our research on perception and signaling of MAMPs in plants we will, using the same set-up, look for compounds that might prevent or reduce the entry of pathogens through the stomatal pore.
    Funded by FTP (2015-2018)

  • Coordinator: Anja Thoe Fuglsang

  • Partners: Mari-Anne Newman, Thomas Ostenfeld Larsen (DTU)

  • Cellular effects of proton pump inhibition in S. cerevisiae

  • Fungal plasma membrane H+-ATPases is potential drug targets, as humans do not posses homologs enzymes. Our part of this project is to understand the cellular effects and responses upon inhibition of the fungal plasma membrane H+-ATPase. We have established new methods for detection of membrane potential and membrane integrity in living cells. These are used in addition to the broad range of classical biochemical assays employed in the laboratory.

  • Industrial PhD project funded by the Innovation Foundation and Pcovery (2014-2018).

    • Gruppemedlemmer

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