Research Group: Plant Development
Forskergruppen Plant Development undersøger, hvordan udviklingsprocesserne reguleres, hvordan de kan styres, og hvordan de ændrer sig som respons på miljømæssige ændringer (f.eks. lys).
Gruppen har særligt fokus på mikroProteiner. MikroProteiner er små regulatoriske proteiner, der kan danne proteinkomplekser med deres mål, hvilket i høj grad kan påvirke deres biologiske aktivitet.
Til indgående studier af plante-mikroProteiner anvendes adskillige teknologiplatforme: 1) genom-resekventering af EMS-suppressormutanter 2) berigelsesproteomik 3) anvendelsen af syntetiske mikroProteiner udvidede vores sæt af værktøjer til regulering af biologiske veje 4) CRISPR-Cas9-styret genmodifikation.
- MicroProteins: We have uncovered the regulation of protein activity by small proteins, known as microProteins. These microProteins establish feedback loops and we can use genome-engineering to rewire signaling pathways.
- Light-regulated development: We work on transcription factors and microProteins that control light-dependent growth responses.
- Biotechnology: How can we use our findings in model plants to improve the growth of crop plants? This is a central theme in our group and we have recently shown that we can use microProteins to manipulate the growth of crop plants.
- Novo Nordisk Biotechnology Based Synthesis Project Grant ‘Increasing folate levels in crop plants by microProtein-engineering’: We have identified novel microProteins in crops that are related to metabolic enzymes. Goal of the project is to rewire the production of folate.
- Novo Nordisk Foundation Exploratory Interdisciplinary Synergy grant ‘QuantumBioengineering - Developing a next-generation magneto-sensitive optogenetic system’: Together with researchers from DTU Physics and Sorbonne University, Paris, France we are aiming to develop a magneto-sensitive optogenetic switch.
- NovoCrops - Accelerated domestication of resilient climate-change friendly plant species: In this project we will use genome-engineering to improve growth and development of alfalfa using genome-engineering.
- Novo Nordisk Foundation Ascending Investigator grant ' MORE – MicroProtein-engineering to Optimize plant development to increase REsources': In this project we will employ CRISPR/Cas9-based genome engineering to modify microProtein pathways in crop plants.
- The Danish Agency for Science, Technology and Innovation ' UnZIPping tomato fruit production': This project aims to manipulate the LITTLE ZIPPER microProteins in tomato
- The Danish Agency for Science, Technology and Innovation (FNU) ‘Adapting to change – The role of alternative microProteins unfolding their hidden potential’: This project aims to identify alternative microProteins that are hidden in the genome and we will elucidate their biological potential.
Hvis du er interesseret i at lave et projekt, kan du læse mere om dine muligheder i projektdatabasen:
Institut for Plante- og Miljøvidenskab har forskellige bachelor- og kandidatuddannelser:
Hong SY, Sun B, Straub D, Blaakmeer A, Mineri L, Koch J, Brinch-Pedersen H, Holme IB, Burow M, Jørgensen HJL, Albà MM and Wenkel S.
Heterologous microProtein expression identifies LITTLE NINJA, a dominant regulator of jasmonic acid signaling
PNAS 117(42):26197-26205, 2020
Bhati KK, Kruusvee V, Straub D, Chandran AKN, Jung KH and Wenkel S.
Global analysis of cereal microProteins suggests diverse roles in crop development and environmental adaptation
G3: Genes | Genomes | Genetics 10(10):3709-3717, 2020
Hong SY, Botterweg-Paredes E, Doll J, Eguen T, Blaakmeer A, Xie Y, Matton, SEA, Lunding BS, Zentgraf U, Guan C, Jiao Y and Wenkel S.
Multi-level analysis of the interactions between REVOLUTA and MORE AXILLARY BRANCHES2 in controlling plant development reveals parallel, independent and antagonistic functions.
Development 147(10):dev183681, 2020
Botterweg-Paredes E, Blaakmeer A, Hong SY, Sun B, Mineri L, Kruusvee V, Xie Y, Straub D, Menard D, Pesquet E and Wenkel S
Light affects tissue patterning of the hypocotyl in the shade-avoidance response.
PLoS Genetics 6(3):e1008678, 2020
DeHann L, Larson S, Lopez-Marquez RL, Wenkel S, Gao X and Palmgren M.
Roadmap for accelerated domestication of a future perennial grain crop.
Trends in Plant Science 25(6):525-537, 2020
Eguen T, Gomez Ariza J, Bhati K, Sun B, Fornara F and Wenkel S.
Control of flowering in rice through synthetic microProteins.
Journal of Integrative Plant Biology 62(6):730-736, 2020
Dolde U, Rodrigues V, Straub D, Bhati K, Choi S, Yang SW, Wenkel S.
Synthetic microProteins – versatile tools for post-translational regulation of target proteins.
Plant Physiology 176(4):3136-3145, 2018
Full publication list, please see: https://pubmed.ncbi.nlm.nih.gov/?term=wenkel+s&sort=date
We were the first…
- to characterize the first plant microProteins (see Wenkel et al., Plant Cell, 2007).
- to coin the microProtein concept (see Staudt and Wenkel, EMBO Reports 2011).
- to identify microProteins involved in the control of flowering (see Graeff et al., PLoS Genetics, 2016)
- to CRISPR/Cas9-engineer a microProtein in a genome where it naturally not exists (see Hong et al., PNAS, 2020)
Gruppemedlemmer
Navn | Titel | Telefon | |
---|---|---|---|
Bin Sun | Postdoc | +45 353-30328 | |
Louise Petri | Ph.d.-stipendiat | +45 353-33610 | |
Maurizio Junior Chiurazzi | Ph.d.-stipendiat | +45 353-20281 | |
Teinai Ebimienere Eguen | Adjunkt | +45 353-37745 | |
Valdeko Kruusvee | Postdoc | +45 353-36246 |
Specialestuderende
- Quingyuan Han
- Sihua Zhu
- Ylenia Vittozzi
- Ashleigh Edwards
Kontakt forskergruppeleder
Stephan Wenkel
Lektor
E-mail: wenkel@plen.ku.dk
Tlf.: +45 35 33 75 67
Nyheder fra Plantebiokemi
-
EliteScience Travel Grant for Victor Forman
27.02.2020 -
Danske forskere afslører hvordan giftige mandler blev spiselige
18.06.2019 -
Danish researchers unravel how toxic almonds became edible
17.06.2019 -
EliteScience Travel Grant for Cecilie Cetti Hansen
01.03.2019 -
Saponins – eco-friendly pesticides
09.11.2018 -
Plant-based bioactive compounds for medical and agrochemical applications
09.11.2018