The plasma membrane H+-ATPase, a simple polypeptide with a long history

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The plasma membrane H+-ATPase of fungi and plants is a single polypeptide of fewer than 1,000 residues that extrudes protons from the cell against a large electric and concentration gradient. The minimalist structure of this nanomachine is in stark contrast to that of the large multi-subunit FOF1 ATPase of mitochondria, which is also a proton pump, but under physiological conditions runs in the reverse direction to act as an ATP synthase. The plasma membrane H+-ATPase is a P-type ATPase, defined by having an obligatory phosphorylated reaction cycle intermediate, like cation pumps of animal membranes, and thus, this pump has a completely different mechanism to that of FOF1 ATPases, which operates by rotary catalysis. The work that led to these insights in plasma membrane H+-ATPases of fungi and plants has a long history, which is briefly summarized in this review.

Original languageEnglish
JournalYeast
Volume36
Issue number4
Pages (from-to)201-210
ISSN0749-503X
DOIs
Publication statusPublished - Apr 2019

    Research areas

  • Arabidopsis thaliana, F-type ATPase, Neurospora crassa, Nicotiana tabacum, P-type ATPase, proton pump, Saccharomyces cerevisiae, Schizosaccharomyces pombe

ID: 213856468