Evidence for suppression of immunity as a driver for genomic introgressions and host range expansion in races of Albugo candida, a generalist parasite

Research output: Contribution to journalJournal article

  • Mark McMullan
  • Anastasia Gardiner
  • Kate Bailey
  • Eric Kemen
  • Ben J Ward
  • Volkan Cevik
  • Alexandre Robert-Seilaniantz
  • Torsten Schultz-Larsen
  • Alexi Balmuth
  • Eric Holub
  • Cock van Oosterhout
  • Jonathan DG Jones
  • Detlef Weigel (Editor)
How generalist parasites with wide host ranges can evolve is a central question in parasite evolution. Albugo candida is an obligate biotrophic parasite that consists of many physiological races that each specialize on distinct Brassicaceae host species. By analyzing genome sequence assemblies of five isolates, we show they represent three races that are genetically diverged by ∼1%. Despite this divergence, their genomes are mosaic-like, with ∼25% being introgressed from other races. Sequential infection experiments show that infection by adapted races enables subsequent infection of hosts by normally non-infecting races. This facilitates introgression and the exchange of effector repertoires, and may enable the evolution of novel races that can undergo clonal population expansion on new hosts. We discuss recent studies on hybridization in other eukaryotes such as yeast, Heliconius butterflies, Darwin's finches, sunflowers and cichlid fishes, and the implications of introgression for pathogen evolution in an agro-ecological environment.
Original languageDanish
Article numbere04550
JournaleLife
Volume4
Number of pages24
ISSN2050-084X
DOIs
Publication statusPublished - 2015

ID: 156083144