Evidence for suppression of immunity as a driver for genomic introgressions and host range expansion in races of Albugo candida, a generalist parasite
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Evidence for suppression of immunity as a driver for genomic introgressions and host range expansion in races of Albugo candida, a generalist parasite. / McMullan, Mark; Gardiner, Anastasia; Bailey, Kate; Kemen, Eric; Ward, Ben J; Cevik, Volkan; Robert-Seilaniantz, Alexandre; Schultz-Larsen, Torsten; Balmuth, Alexi; Holub, Eric; van Oosterhout, Cock; Jones, Jonathan DG; Weigel, Detlef (Editor).
In: eLife, Vol. 4, e04550, 2015.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Evidence for suppression of immunity as a driver for genomic introgressions and host range expansion in races of Albugo candida, a generalist parasite
AU - McMullan, Mark
AU - Gardiner, Anastasia
AU - Bailey, Kate
AU - Kemen, Eric
AU - Ward, Ben J
AU - Cevik, Volkan
AU - Robert-Seilaniantz, Alexandre
AU - Schultz-Larsen, Torsten
AU - Balmuth, Alexi
AU - Holub, Eric
AU - van Oosterhout, Cock
AU - Jones, Jonathan DG
A2 - Weigel, Detlef
PY - 2015
Y1 - 2015
N2 - How generalist parasites with wide host ranges can evolve is a central question in parasite evolution. Albugo candida is an obligate biotrophic parasite that consists of many physiological races that each specialize on distinct Brassicaceae host species. By analyzing genome sequence assemblies of five isolates, we show they represent three races that are genetically diverged by ∼1%. Despite this divergence, their genomes are mosaic-like, with ∼25% being introgressed from other races. Sequential infection experiments show that infection by adapted races enables subsequent infection of hosts by normally non-infecting races. This facilitates introgression and the exchange of effector repertoires, and may enable the evolution of novel races that can undergo clonal population expansion on new hosts. We discuss recent studies on hybridization in other eukaryotes such as yeast, Heliconius butterflies, Darwin's finches, sunflowers and cichlid fishes, and the implications of introgression for pathogen evolution in an agro-ecological environment.
AB - How generalist parasites with wide host ranges can evolve is a central question in parasite evolution. Albugo candida is an obligate biotrophic parasite that consists of many physiological races that each specialize on distinct Brassicaceae host species. By analyzing genome sequence assemblies of five isolates, we show they represent three races that are genetically diverged by ∼1%. Despite this divergence, their genomes are mosaic-like, with ∼25% being introgressed from other races. Sequential infection experiments show that infection by adapted races enables subsequent infection of hosts by normally non-infecting races. This facilitates introgression and the exchange of effector repertoires, and may enable the evolution of novel races that can undergo clonal population expansion on new hosts. We discuss recent studies on hybridization in other eukaryotes such as yeast, Heliconius butterflies, Darwin's finches, sunflowers and cichlid fishes, and the implications of introgression for pathogen evolution in an agro-ecological environment.
KW - Albugo candida
KW - oomycete
KW - mosaic genome
KW - recombination
KW - introgression
KW - hybridization
U2 - 10.7554/eLife.04550
DO - 10.7554/eLife.04550
M3 - Tidsskriftartikel
C2 - 25723966
VL - 4
JO - eLife
JF - eLife
SN - 2050-084X
M1 - e04550
ER -
ID: 156083144