Evidence for suppression of immunity as a driver for genomic introgressions and host range expansion in races of Albugo candida, a generalist parasite

Research output: Contribution to journalJournal articleResearchpeer-review

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Evidence for suppression of immunity as a driver for genomic introgressions and host range expansion in races of Albugo candida, a generalist parasite. / McMullan, Mark; Gardiner, Anastasia; Bailey, Kate; Kemen, Eric; Ward, Ben J; Cevik, Volkan; Robert-Seilaniantz, Alexandre; Schultz-Larsen, Torsten; Balmuth, Alexi; Holub, Eric; van Oosterhout, Cock; Jones, Jonathan DG; Weigel, Detlef (Editor).

In: eLife, Vol. 4, e04550, 2015.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

McMullan, M, Gardiner, A, Bailey, K, Kemen, E, Ward, BJ, Cevik, V, Robert-Seilaniantz, A, Schultz-Larsen, T, Balmuth, A, Holub, E, van Oosterhout, C, Jones, JDG & Weigel, D (ed.) 2015, 'Evidence for suppression of immunity as a driver for genomic introgressions and host range expansion in races of Albugo candida, a generalist parasite', eLife, vol. 4, e04550. https://doi.org/10.7554/eLife.04550

APA

McMullan, M., Gardiner, A., Bailey, K., Kemen, E., Ward, B. J., Cevik, V., ... Weigel, D. (Ed.) (2015). Evidence for suppression of immunity as a driver for genomic introgressions and host range expansion in races of Albugo candida, a generalist parasite. eLife, 4, [e04550]. https://doi.org/10.7554/eLife.04550

Vancouver

McMullan M, Gardiner A, Bailey K, Kemen E, Ward BJ, Cevik V et al. Evidence for suppression of immunity as a driver for genomic introgressions and host range expansion in races of Albugo candida, a generalist parasite. eLife. 2015;4. e04550. https://doi.org/10.7554/eLife.04550

Author

McMullan, Mark ; Gardiner, Anastasia ; Bailey, Kate ; Kemen, Eric ; Ward, Ben J ; Cevik, Volkan ; Robert-Seilaniantz, Alexandre ; Schultz-Larsen, Torsten ; Balmuth, Alexi ; Holub, Eric ; van Oosterhout, Cock ; Jones, Jonathan DG ; Weigel, Detlef (Editor). / Evidence for suppression of immunity as a driver for genomic introgressions and host range expansion in races of Albugo candida, a generalist parasite. In: eLife. 2015 ; Vol. 4.

Bibtex

@article{50de6fab86ab49df842c14412b5769ce,
title = "Evidence for suppression of immunity as a driver for genomic introgressions and host range expansion in races of Albugo candida, a generalist parasite",
abstract = "How generalist parasites with wide host ranges can evolve is a central question in parasite evolution. Albugo candida is an obligate biotrophic parasite that consists of many physiological races that each specialize on distinct Brassicaceae host species. By analyzing genome sequence assemblies of five isolates, we show they represent three races that are genetically diverged by ∼1{\%}. Despite this divergence, their genomes are mosaic-like, with ∼25{\%} being introgressed from other races. Sequential infection experiments show that infection by adapted races enables subsequent infection of hosts by normally non-infecting races. This facilitates introgression and the exchange of effector repertoires, and may enable the evolution of novel races that can undergo clonal population expansion on new hosts. We discuss recent studies on hybridization in other eukaryotes such as yeast, Heliconius butterflies, Darwin's finches, sunflowers and cichlid fishes, and the implications of introgression for pathogen evolution in an agro-ecological environment.",
keywords = "Albugo candida, oomycete, mosaic genome, recombination, introgression, hybridization",
author = "Mark McMullan and Anastasia Gardiner and Kate Bailey and Eric Kemen and Ward, {Ben J} and Volkan Cevik and Alexandre Robert-Seilaniantz and Torsten Schultz-Larsen and Alexi Balmuth and Eric Holub and {van Oosterhout}, Cock and Jones, {Jonathan DG} and Detlef Weigel",
year = "2015",
doi = "10.7554/eLife.04550",
language = "Dansk",
volume = "4",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications Ltd.",

}

RIS

TY - JOUR

T1 - Evidence for suppression of immunity as a driver for genomic introgressions and host range expansion in races of Albugo candida, a generalist parasite

AU - McMullan, Mark

AU - Gardiner, Anastasia

AU - Bailey, Kate

AU - Kemen, Eric

AU - Ward, Ben J

AU - Cevik, Volkan

AU - Robert-Seilaniantz, Alexandre

AU - Schultz-Larsen, Torsten

AU - Balmuth, Alexi

AU - Holub, Eric

AU - van Oosterhout, Cock

AU - Jones, Jonathan DG

A2 - Weigel, Detlef

PY - 2015

Y1 - 2015

N2 - How generalist parasites with wide host ranges can evolve is a central question in parasite evolution. Albugo candida is an obligate biotrophic parasite that consists of many physiological races that each specialize on distinct Brassicaceae host species. By analyzing genome sequence assemblies of five isolates, we show they represent three races that are genetically diverged by ∼1%. Despite this divergence, their genomes are mosaic-like, with ∼25% being introgressed from other races. Sequential infection experiments show that infection by adapted races enables subsequent infection of hosts by normally non-infecting races. This facilitates introgression and the exchange of effector repertoires, and may enable the evolution of novel races that can undergo clonal population expansion on new hosts. We discuss recent studies on hybridization in other eukaryotes such as yeast, Heliconius butterflies, Darwin's finches, sunflowers and cichlid fishes, and the implications of introgression for pathogen evolution in an agro-ecological environment.

AB - How generalist parasites with wide host ranges can evolve is a central question in parasite evolution. Albugo candida is an obligate biotrophic parasite that consists of many physiological races that each specialize on distinct Brassicaceae host species. By analyzing genome sequence assemblies of five isolates, we show they represent three races that are genetically diverged by ∼1%. Despite this divergence, their genomes are mosaic-like, with ∼25% being introgressed from other races. Sequential infection experiments show that infection by adapted races enables subsequent infection of hosts by normally non-infecting races. This facilitates introgression and the exchange of effector repertoires, and may enable the evolution of novel races that can undergo clonal population expansion on new hosts. We discuss recent studies on hybridization in other eukaryotes such as yeast, Heliconius butterflies, Darwin's finches, sunflowers and cichlid fishes, and the implications of introgression for pathogen evolution in an agro-ecological environment.

KW - Albugo candida

KW - oomycete

KW - mosaic genome

KW - recombination

KW - introgression

KW - hybridization

U2 - 10.7554/eLife.04550

DO - 10.7554/eLife.04550

M3 - Tidsskriftartikel

C2 - 25723966

VL - 4

JO - eLife

JF - eLife

SN - 2050-084X

M1 - e04550

ER -

ID: 156083144