Engineering Barriers to Infection by Undermining Pathogen Effector Function or by Gaining Effector Recognition

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This chapter reviews potential disease control strategies by employing the current understanding of Pathogen-Associated Molecular Patterns (PAMPs) and their receptors, as well as effectors and their targets. It discusses how effectoromics, i.e. surveying which, and to what level, effectors are expressed at a pathogen population level, can help to select the most useful and durable R genes. Plant immunity can be boosted by overexpressing a Pattern-Recognition Receptor (PRR) in a closely- or more-distantly related plant to strengthen PAMP-Triggered Immunity (PTI). An interesting aspect of NB-LRR transcript regulation that involves small RNAs is currently emerging and could potentially be explored in the search for more durable and/or broad-spectrum pathogen resistance. The chapter suggests ways that can be used to undermine effector function and be exploited to engineer resistant plants in the future. It further illustrates how a mechanistic understanding of a pathogen's stealth strategies may allow new approaches to engineer resistance.

Original languageEnglish
Title of host publicationPlant Pathogen Resistance Biotechnology
EditorsDavid B. Collinge
Number of pages29
Publication date2016
ISBN (Print)9781118867761
ISBN (Electronic)9781118867716
Publication statusPublished - 2016

    Research areas

  • Effector recognition, Effectoromics, Engineering resistance, NB-LRR-type resistance proteins, PAMP-triggered immunity, Pathogen effector function, Pattern recognition receptor, Plant defence

ID: 178847110