Engineering Barriers to Infection by Undermining Pathogen Effector Function or by Gaining Effector Recognition
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Engineering Barriers to Infection by Undermining Pathogen Effector Function or by Gaining Effector Recognition. / Ahmed, Ali Abdurehim; Mclellan, Hazel; Aguilar, Geziel Barbosa; Hein, Ingo; Thordal-Christensen, Hans; Birch, Paul R.J.
Plant Pathogen Resistance Biotechnology. ed. / David B. Collinge. Wiley-Blackwell, 2016. p. 23-50.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Engineering Barriers to Infection by Undermining Pathogen Effector Function or by Gaining Effector Recognition
AU - Ahmed, Ali Abdurehim
AU - Mclellan, Hazel
AU - Aguilar, Geziel Barbosa
AU - Hein, Ingo
AU - Thordal-Christensen, Hans
AU - Birch, Paul R.J.
PY - 2016
Y1 - 2016
N2 - This chapter reviews potential disease control strategies by employing the current understanding of Pathogen-Associated Molecular Patterns (PAMPs) and their receptors, as well as effectors and their targets. It discusses how effectoromics, i.e. surveying which, and to what level, effectors are expressed at a pathogen population level, can help to select the most useful and durable R genes. Plant immunity can be boosted by overexpressing a Pattern-Recognition Receptor (PRR) in a closely- or more-distantly related plant to strengthen PAMP-Triggered Immunity (PTI). An interesting aspect of NB-LRR transcript regulation that involves small RNAs is currently emerging and could potentially be explored in the search for more durable and/or broad-spectrum pathogen resistance. The chapter suggests ways that can be used to undermine effector function and be exploited to engineer resistant plants in the future. It further illustrates how a mechanistic understanding of a pathogen's stealth strategies may allow new approaches to engineer resistance.
AB - This chapter reviews potential disease control strategies by employing the current understanding of Pathogen-Associated Molecular Patterns (PAMPs) and their receptors, as well as effectors and their targets. It discusses how effectoromics, i.e. surveying which, and to what level, effectors are expressed at a pathogen population level, can help to select the most useful and durable R genes. Plant immunity can be boosted by overexpressing a Pattern-Recognition Receptor (PRR) in a closely- or more-distantly related plant to strengthen PAMP-Triggered Immunity (PTI). An interesting aspect of NB-LRR transcript regulation that involves small RNAs is currently emerging and could potentially be explored in the search for more durable and/or broad-spectrum pathogen resistance. The chapter suggests ways that can be used to undermine effector function and be exploited to engineer resistant plants in the future. It further illustrates how a mechanistic understanding of a pathogen's stealth strategies may allow new approaches to engineer resistance.
KW - Effector recognition
KW - Effectoromics
KW - Engineering resistance
KW - NB-LRR-type resistance proteins
KW - PAMP-triggered immunity
KW - Pathogen effector function
KW - Pattern recognition receptor
KW - Plant defence
U2 - 10.1002/9781118867716.ch2
DO - 10.1002/9781118867716.ch2
M3 - Book chapter
AN - SCOPUS:85017660801
SN - 9781118867761
SP - 23
EP - 50
BT - Plant Pathogen Resistance Biotechnology
A2 - Collinge, David B.
PB - Wiley-Blackwell
ER -
ID: 178847110