An NPF transporter exports a central monoterpene indole alkaloid intermediate from the vacuole

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

An NPF transporter exports a central monoterpene indole alkaloid intermediate from the vacuole. / Payne, Richard; Xu, Deyang; Foureau, Emilien; Ines Soares Teto Carqueijeiro, Marta; Oudin, Audrey; Dugé de Bernonville, Thomas; Novák, Vlastimil; Burow, Meike; Olsen, Carl Erik; Jones, D. Marc; C. Tatsis, Evangelos; Pendleton, Ali; Halkier, Barbara Ann; Geu-Flores, Fernando; Courdavault, Vincent; Nour-Eldin, Hussam Hassan; O'Connor, Sarah E.

In: Nature Plants, Vol. 3, 16208, 2017.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Payne, R, Xu, D, Foureau, E, Ines Soares Teto Carqueijeiro, M, Oudin, A, Dugé de Bernonville, T, Novák, V, Burow, M, Olsen, CE, Jones, DM, C. Tatsis, E, Pendleton, A, Halkier, BA, Geu-Flores, F, Courdavault, V, Nour-Eldin, HH & O'Connor, SE 2017, 'An NPF transporter exports a central monoterpene indole alkaloid intermediate from the vacuole', Nature Plants, vol. 3, 16208. https://doi.org/10.1038/nplants.2016.208

APA

Payne, R., Xu, D., Foureau, E., Ines Soares Teto Carqueijeiro, M., Oudin, A., Dugé de Bernonville, T., ... O'Connor, S. E. (2017). An NPF transporter exports a central monoterpene indole alkaloid intermediate from the vacuole. Nature Plants, 3, [16208]. https://doi.org/10.1038/nplants.2016.208

Vancouver

Payne R, Xu D, Foureau E, Ines Soares Teto Carqueijeiro M, Oudin A, Dugé de Bernonville T et al. An NPF transporter exports a central monoterpene indole alkaloid intermediate from the vacuole. Nature Plants. 2017;3. 16208. https://doi.org/10.1038/nplants.2016.208

Author

Payne, Richard ; Xu, Deyang ; Foureau, Emilien ; Ines Soares Teto Carqueijeiro, Marta ; Oudin, Audrey ; Dugé de Bernonville, Thomas ; Novák, Vlastimil ; Burow, Meike ; Olsen, Carl Erik ; Jones, D. Marc ; C. Tatsis, Evangelos ; Pendleton, Ali ; Halkier, Barbara Ann ; Geu-Flores, Fernando ; Courdavault, Vincent ; Nour-Eldin, Hussam Hassan ; O'Connor, Sarah E. / An NPF transporter exports a central monoterpene indole alkaloid intermediate from the vacuole. In: Nature Plants. 2017 ; Vol. 3.

Bibtex

@article{1df9f27626934970857744ded38a503a,
title = "An NPF transporter exports a central monoterpene indole alkaloid intermediate from the vacuole",
abstract = "Plants sequester intermediates of metabolic pathways into different cellular compartments, but the mechanisms by which these molecules are transported remain poorly understood. Monoterpene indole alkaloids, a class of specialized metabolites that includes the anticancer agent vincristine, antimalarial quinine and neurotoxin strychnine, are synthesized in several different cellular locations. However, the transporters that control the movement of these biosynthetic intermediates within cellular compartments have not been discovered. Here we present the discovery of a tonoplast localized nitrate/peptide family (NPF) transporter from Catharanthus roseus, CrNPF2.9, that exports strictosidine, the central intermediate of this pathway, into the cytosol from the vacuole. This discovery highlights the role that intracellular localization plays in specialized metabolism, and sets the stage for understanding and controlling the central branch point of this pharmacologically important group of compounds.",
author = "Richard Payne and Deyang Xu and Emilien Foureau and {Ines Soares Teto Carqueijeiro}, Marta and Audrey Oudin and {Dug{\'e} de Bernonville}, Thomas and Vlastimil Nov{\'a}k and Meike Burow and Olsen, {Carl Erik} and Jones, {D. Marc} and {C. Tatsis}, Evangelos and Ali Pendleton and Halkier, {Barbara Ann} and Fernando Geu-Flores and Vincent Courdavault and Nour-Eldin, {Hussam Hassan} and O'Connor, {Sarah E}",
year = "2017",
doi = "10.1038/nplants.2016.208",
language = "English",
volume = "3",
journal = "Nature Plants",
issn = "2055-026X",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - An NPF transporter exports a central monoterpene indole alkaloid intermediate from the vacuole

AU - Payne, Richard

AU - Xu, Deyang

AU - Foureau, Emilien

AU - Ines Soares Teto Carqueijeiro, Marta

AU - Oudin, Audrey

AU - Dugé de Bernonville, Thomas

AU - Novák, Vlastimil

AU - Burow, Meike

AU - Olsen, Carl Erik

AU - Jones, D. Marc

AU - C. Tatsis, Evangelos

AU - Pendleton, Ali

AU - Halkier, Barbara Ann

AU - Geu-Flores, Fernando

AU - Courdavault, Vincent

AU - Nour-Eldin, Hussam Hassan

AU - O'Connor, Sarah E

PY - 2017

Y1 - 2017

N2 - Plants sequester intermediates of metabolic pathways into different cellular compartments, but the mechanisms by which these molecules are transported remain poorly understood. Monoterpene indole alkaloids, a class of specialized metabolites that includes the anticancer agent vincristine, antimalarial quinine and neurotoxin strychnine, are synthesized in several different cellular locations. However, the transporters that control the movement of these biosynthetic intermediates within cellular compartments have not been discovered. Here we present the discovery of a tonoplast localized nitrate/peptide family (NPF) transporter from Catharanthus roseus, CrNPF2.9, that exports strictosidine, the central intermediate of this pathway, into the cytosol from the vacuole. This discovery highlights the role that intracellular localization plays in specialized metabolism, and sets the stage for understanding and controlling the central branch point of this pharmacologically important group of compounds.

AB - Plants sequester intermediates of metabolic pathways into different cellular compartments, but the mechanisms by which these molecules are transported remain poorly understood. Monoterpene indole alkaloids, a class of specialized metabolites that includes the anticancer agent vincristine, antimalarial quinine and neurotoxin strychnine, are synthesized in several different cellular locations. However, the transporters that control the movement of these biosynthetic intermediates within cellular compartments have not been discovered. Here we present the discovery of a tonoplast localized nitrate/peptide family (NPF) transporter from Catharanthus roseus, CrNPF2.9, that exports strictosidine, the central intermediate of this pathway, into the cytosol from the vacuole. This discovery highlights the role that intracellular localization plays in specialized metabolism, and sets the stage for understanding and controlling the central branch point of this pharmacologically important group of compounds.

U2 - 10.1038/nplants.2016.208

DO - 10.1038/nplants.2016.208

M3 - Journal article

C2 - 28085153

VL - 3

JO - Nature Plants

JF - Nature Plants

SN - 2055-026X

M1 - 16208

ER -

ID: 172026732