Plant Biochemistry Employees – Institut for Plante- og Miljøvidenskab - Københavns Universitet

Shinyoung Hong

Shinyoung Hong


MicroProteins as modulators for protein function

Many proteins function as part of multi-proteins complex. Proteins dynamically interact with each other to regulate and mediate through defined protein-protein interaction (PPI) domains. Interestingly, small proteins that competitively form heterodimers with larger proteins having the same protein-protein-interaction domain have been identified. Because of their dominant-negative mode of action, these proteins have been coined microProteins.

MicroProteins (miPs) are short, single domain proteins that behave as post-translational regulators by forming heterodimers with their targets. They achieve their function which regulates transcriptional activity or DNA-binding affinity of transcriptional regulators through the dominant-negative suppression of protein complex. All know microProteins function in plant developmental processes.

In contrast to the general action of miPs as negative regulators of protein function, little is known about miP formation. How did miPs arise? Which conditions or factors involved in miP formation? By investigating the properties of miP expression in diverse environmental cues and in the computational information,

I study to find particular conditions or factors involved in the microProtein formation. This approach will contribute to understanding the architecture of microProteins regulatory network and their generation. I also study microProtein function in Brachypodium, monocot model plant.

ID: 135838035