Functional plant cell wall genomics – University of Copenhagen

Functional plant cell wall genomics

The group is interested in the question 'Can we infer gene function if sufficient evolutionary sequence information are available?'
Based bioinformatic analysis of de novo sequenced genomes and transcriptomes and in conjugation with a thorough analysis of the cell wall structure of the species under investigation we are gaining valuble knowledge on gene function and evolution of glycosyltransferases. Using evolutionary information from the genomic or transcriptomic work reverse genetic tools is used in Arabidopsis to expand the functionality studies initiated in the genomic or transcriptomic screens.

The research group is involved in ongoing research to employ and develop state of the art tools for structural and compositional analysis of polysaccharides.  Ad hoc to the polysaccharide analyses, we are involved in collaborative work on soluble sugars and glycosides with internal and external researchers.

Selected publications

  • Ulvskov P, Paiva DS, Domozych D, Harholt J (2013) Classification, naming and evolutionary history of glycosyltransferases from sequenced green and red algal genomes. PLOS ONE doi: 10.1371/journal.pone.0076511.
  • Amborella Genome Project (2013) The Amborella Genome and the Evolution of Flowering Plants. Science, 342 (6165), 1241089.
  • Harholt J, Sorensen I, Fangel J, Roberts A, Willats WG, Scheller HV, Petersen BL, Banks JA, Ulvskov P (2012) The Glycosyltransferase Repertoire of the Spikemoss Selaginella moellendorffii and a Comparative Study of Its Cell Wall. PLOS ONE 7: e35846.
  • Harholt J, Jensen JK, Verhertbruggen Y, Søgaard C, Bernard S, Nafisi M, Poulsen CP, Geshi N, Sakuragi Y, Driouich A, Knox JP, Scheller HV (2012) ARAD proteins associated with pectic arabinan biosynthesis form complexes when transiently overexpressed in planta. Planta 236:115-128.